The Roles of Xenobiotic Receptors: Beyond Chemical Disposition

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Bryan MackowiakHongbing Wang

Abstract

Over the past 20 years, the ability of the xenobiotic receptors to coordinate an array of drug-metabolizing enzymes and transporters in response to endogenous and exogenous stimuli has been extensively characterized and well documented. The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are the xenobiotic receptors that have received the most attention since they regulate the expression of numerous proteins important to drug metabolism and clearance and formulate a central defensive mechanism to protect the body against xenobiotic challenges. However, accumulating evidence has shown that these xenobiotic sensors also control many cellular processes outside of their traditional realms of xenobiotic metabolism and disposition, including physiologic and/or pathophysiologic responses in energy homeostasis, cell proliferation, inflammation, tissue injury and repair, immune response, and cancer development. This review will highlight recent advances in studying the noncanonical functions of xenobiotic receptors with a particular focus placed on the roles of CAR and PXR in energy homeostasis and cancer development.

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Citations

Dec 30, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joseph L Dempsey, Julia Yue Cui
Mar 27, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·C J HendersonC R Wolf
Sep 1, 2019·International Journal of Molecular Sciences·Deborah MinzaghiSandrine Dubrac
Nov 30, 2019·Medicinal Research Reviews·Sergio C ChaiTaosheng Chen
Oct 21, 2020·Cells·Jenni KüblbeckPaavo Honkakoski
Aug 14, 2020·The Journal of Biological Chemistry·Masahiko NegishiTatsuya Sueyoshi
Nov 5, 2020·Cells·Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin
Aug 18, 2020·Regulatory Toxicology and Pharmacology : RTP·Christian StruppPramila Singh
May 10, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yabing DuKang Cui
Aug 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chunzhan WangHaitao Huang
Sep 2, 2021·Drug Discovery Today·Lap Hing ChiRobin L Anderson
Sep 30, 2021·Cellular and Molecular Life Sciences : CMLS·Samiksha KukalRitushree Kukreti

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