The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance

Fungal Genetics and Biology : FG & B
Taísa Magnani DinamarcoGustavo Henrique Goldman

Abstract

Farnesol (FOH) is a nonsterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, a catabolite of the cholesterol biosynthetic pathway. These isoprenoids inhibit proliferation and induce apoptosis. Here, we show that Aspergillus nidulans AifA encoding the apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase plays a role in the function of the mitochondrial Complex I. Additionally, we demonstrated that ndeA-B and ndiA encode external and internal alternative NADH dehydrogenases, respectively, that have a function in FOH resistance. When exposed to FOH, the ΔaifA and ΔndeA strains have increased ROS production while ΔndeB, ΔndeA ΔndeB, and ΔndiA mutant strains showed the same ROS accumulation than in the absence of FOH. We observed several compensatory mechanisms affecting the differential survival of these mutants to FOH.

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Citations

Dec 7, 2010·Eukaryotic Cell·Bárbara de Castro Pimentel FigueiredoGustavo Henrique Goldman
Apr 4, 2012·PloS One·Patrícia CarneiroArnaldo Videira
Mar 15, 2016·Journal of Basic Microbiology·Thanwa WongsukNatthanej Luplertlop
Nov 26, 2010·Molecular Microbiology·Ana Cristina ColabardiniGustavo Henrique Goldman
Nov 17, 2012·Microbiology·Melinda SzilágyiTamás Emri
Feb 11, 2015·International Journal of Medical Microbiology : IJMM·Susanne PerkhoferCornelia Lass-Flörl
Sep 23, 2011·Biochemical Society Transactions·Taísa Magnani DinamarcoGustavo Henrique Goldman
Nov 7, 2013·G3 : Genes - Genomes - Genetics·Nadia Graciele KrohnGustavo Henrique Goldman
Mar 13, 2015·G3 : Genes - Genomes - Genetics·Leandro José de AssisNeil Andrew Brown
Oct 27, 2018·Expert Opinion on Therapeutic Targets·Éva LeiterIstván Pócsi
Oct 7, 2017·Frontiers in Microbiology·A Pedro GonçalvesN Louise Glass
Aug 5, 2021·Annual Review of Microbiology·Xiuyun TianLinqi Wang

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