The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Liana FattoreO Giorgi

Abstract

The selective breeding of Roman high- (RHA) and low-avoidance (RLA) rats for, respectively, rapid vs extremely poor acquisition of avoidant behavior in a shuttlebox has produced two phenotypes that differ in temperament traits, in mesocortical/mesolimbic dopamine system function, and in the behavioral and neurochemical responses to the acute and repeated administration of psychostimulants and opiates. The phenotypic traits of the RHA line predict higher susceptibility, compared with RLA rats, to the reinforcing properties of addictive substances like cocaine. The present study was designed to compare the acquisition, maintenance, reinstatement of drug-seeking after long-term extinction, and reacquisition of intravenous cocaine self-administration (SA) behavior in the Roman lines. Compared with RLA rats, the rates of responding during cocaine SA acquisition were higher, extinction from cocaine SA was prolonged, and drug-induced reinstatement of cocaine-seeking behavior was more robust in RHA rats. Moreover, only RHA rats reacquired extinguished lever-pressing activity when a low reinforcing dose of cocaine was available. These findings are consistent with the view that subjects with genetically determined high responsiveness to ...Continue Reading

References

Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·B A HorgerS Schenk
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Feb 1, 1986·Archives of General Psychiatry·F H Gawin, H D Kleber
Jan 1, 1981·Psychopharmacology·H de Wit, J Stewart
Jan 1, 1993·Psychopharmacology·A MarkouG F Koob
May 1, 1996·Behavioural Brain Research·M T BardoN G Harrington
Jun 3, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L T Tran-NguyenJ L Neisewander
Aug 12, 1999·American Journal of Human Genetics·T ReichL Bierut
May 2, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M A SuttonD W Self
Jul 13, 2000·Drug and Alcohol Dependence·M M Vanyukov, R E Tarter
Oct 4, 2000·JAMA : the Journal of the American Medical Association·A T McLellanH D Kleber
Jan 3, 2001·European Journal of Pharmacology·R P EbsteinR H Belmaker
Feb 13, 2001·Drug and Alcohol Dependence·T C HelmusC R Schuster
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Dec 26, 2001·Annual Review of Psychology·John C Crabbe
Mar 1, 2002·Pharmacological Reviews·Uri ShalevYavin Shaham
Jul 27, 2002·Trends in Genetics : TIG·George R UhlDaniel Naiman
Aug 20, 2002·Annual Review of Psychology·Terry E Robinson, Kent C Berridge
Oct 18, 2002·Neuron·Aki LaaksoMarc G Caron
Oct 18, 2002·Neuron·Wolfram Schultz
Dec 5, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R Andrew Chambers, David W Self
May 20, 2003·The European Journal of Neuroscience·L FattoreW Fratta
Jun 5, 2003·The American Journal of Psychiatry·R Andrew ChambersMarc N Potenza
Oct 21, 2003·Nature Neuroscience·Colleen A McClung, Eric J Nestler
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·George F KoobPietro Paolo Sanna
Mar 23, 2004·Nature Neuroscience·Rutsuko ItoBarry J Everitt
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise

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Citations

Nov 27, 2009·Journal of the American Society for Mass Spectrometry·Bin HuXiaolin Qiao
Jan 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margarita MorenoPilar Flores
Nov 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Caroline M CoppensJaap M Koolhaas
May 15, 2013·Pharmacology, Biochemistry, and Behavior·Fabrizio SannaOsvaldo Giorgi
May 20, 2014·Experimental Brain Research·Paitoon SrimontriKeiko Kato
May 16, 2014·Physiology & Behavior·Lidia ManzoCarmen Torres
Nov 9, 2010·Cytotechnology·Maria E StefanidouConstantinos P Maravelias
Jul 12, 2012·Cellular and Molecular Life Sciences : CMLS·Chi Chiu WangChristoph Ufer
Feb 22, 2012·Neuroscience and Biobehavioral Reviews·Kanwar VirdeeJeffrey W Dalley
Oct 5, 2011·Neuroscience Letters·Marta SabariegoFrancisco J Esteban
Apr 15, 2014·Acta Clinica Belgica·K KritikosN Mavroidis
Mar 3, 2015·Genes, Brain, and Behavior·T WiltshireL M Tarantino
Dec 12, 2012·Toxicology Mechanisms and Methods·Vasiliki I HatziMaria E Stefanidou
Jun 13, 2015·Physiology & Behavior·S F de BoerJ M Koolhaas
Apr 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Shelly B FlagelHuda Akil
Mar 3, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Liana FattorePaola Fadda
May 4, 2020·Neuroscience and Biobehavioral Reviews·Marjorie C Gondré-LewisKenneth Blum
Nov 19, 2019·Behavioural Brain Research·Amanda M HaskellRichard J Servatius

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