The Route by Which Intranasally Delivered Stem Cells Enter the Central Nervous System

Cell Transplantation
Carlos GaleanoPeter J Hornsby

Abstract

Intranasal administration is a promising route of delivery of stem cells to the central nervous system (CNS). Reports on this mode of stem cell delivery have not yet focused on the route across the cribriform plate by which cells move from the nasal cavity into the CNS. In the current experiments, human mesenchymal stem cells (MSCs) were isolated from Wharton's jelly of umbilical cords and were labeled with extremely bright quantum dots (QDs) in order to track the cells efficiently. At 2 h after intranasal delivery in immunodeficient mice, the labeled cells were found under the olfactory epithelium, crossing the cribriform plate adjacent to the fila olfactoria, and associated with the meninges of the olfactory bulb. At all times, the cells were separate from actual nerve tracts; this location is consistent with them being in the subarachnoid space (SAS) and its extensions through the cribriform plate into the nasal mucosa. In their location under the olfactory epithelium, they appear to be within an expansion of a potential space adjacent to the turbinate bone periosteum. Therefore, intranasally administered stem cells appear to cross the olfactory epithelium, enter a space adjacent to the periosteum of the turbinate bones, and...Continue Reading

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Citations

Jun 17, 2019·Reviews in the Neurosciences·Mahasweta DasSubhra Mohapatra
Jul 25, 2020·Cell Death and Differentiation·Giulia SantamariaClaudia Balducci
Dec 16, 2020·Neural Regeneration Research·Zhong-Yue LvJing Liu
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Mar 26, 2021·Stem Cell Research & Therapy·Yu-Ting ZhangChun-Feng Liu
Apr 13, 2021·Frontiers in Cellular Neuroscience·Yingying ZhaoZheng Zachory Wei
Jul 6, 2021·Pharmaceutical Development and Technology·Rosamaria LombardoRosario Pignatello
Oct 12, 2021·Technology in Cancer Research & Treatment·Sai Priyanka Kodam, Mujib Ullah
Dec 28, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Robert A Yokel

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Methods Mentioned

BETA
dissection
fluorescence imaging
confocal microscopy
fluorescence microscopy
Fluorescence

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