PMID: 4287842Mar 1, 1966Paper

The route of ethanol formation in Zymomonas mobilis

The Biochemical Journal
E A DawesP J Large

Abstract

1. Enzymic evidence supporting the operation of the Entner-Doudoroff pathway in the anaerobic conversion of glucose into ethanol and carbon dioxide by Zymomonas mobilis is presented. 2. Cell extracts catalysed the formation of equimolar amounts of pyruvate and glyceraldehyde 3-phosphate from 6-phosphogluconate. Evidence that 3-deoxy-2-oxo-6-phosphogluconate is an intermediate in this conversion was obtained. 3. Cell extracts of the organism contained the following enzymes: glucose 6-phosphate dehydrogenase (active with NAD and NADP), ethanol dehydrogenase (active with NAD), glyceraldehyde 3-phosphate dehydrogenase (active with NAD), hexokinase, gluconokinase, glucose dehydrogenase and pyruvate decarboxylase. Extracts also catalysed the overall conversion of glycerate 3-phosphate into pyruvate in the presence of ADP. 4. Gluconate dehydrogenase, fructose 1,6-diphosphate aldolase and NAD-NADP transhydrogenase were not detected. 5. It is suggested that NAD is the physiological electron carrier in the balanced oxidation-reduction involved in ethanol formation.

Citations

May 26, 2012·TheScientificWorldJournal·Nina GalininaUldis Kalnenieks
Sep 17, 2013·The FEBS Journal·Helen C HailesMartina Pohl
Jan 1, 1993·Critical Reviews in Biotechnology·H W DoelleM B Doelle
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Sep 27, 2020·Applied and Environmental Microbiology·Amy B BantaJason M Peters
May 13, 2019·Metabolic Engineering·Tyler B JacobsonDaniel Amador-Noguez
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