The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells

International Immunology
Yoshinori NagaiKiyoshi Takatsu

Abstract

Marginal zone (MZ) B cells mount rapid T-cell-independent (T-I) immune responses against microbial components such as LPS. While Toll-like receptor 4 (TLR4) is essential for LPS responses, MZ B cells uniquely express high levels of another LPS sensor Radioprotective 105 (RP105). However, little is known about how RP105 is used by MZ B cells. In this study, we investigated TLR4- or RP105-dependent MZ B cell responses by utilizing agonistic monoclonal antibodies (mAbs) to each receptor. Cross-linking TLR4 and RP105 at the same time with the mAbs induced robust IgM-secreting plasma cell generation as lipid A moiety of LPS. In contrast, stimulation with either mAb alone did not elicit such responses. RP105-deficient MZ B cells failed to produce IgM-secreting plasma cells in response to lipid A. TLR4 or lipid A stimulation of MZ B cells up-regulated their B lymphocyte-induced maturation protein 1 (Blimp-1) and X-box-binding protein 1 (Xbp-1) mRNA expression. RP105 stimulation alone did not give these responses and in fact decreased TLR4-mediated their expression. Compared with wild-type (WT) MZ B cells, RP105-deficient MZ B cells exhibited increased levels of Blimp-1 and Xbp-1 mRNA expression in response to lipid A. Lipid A or TLR4 ...Continue Reading

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Citations

Mar 1, 2012·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Syuichi KoaradaYoshifumi Tada
Jun 13, 2015·International Journal of Molecular Sciences·Kongyang MaLiwei Lu
Jul 7, 2015·Progress in Biophysics and Molecular Biology·Nils A BerglundPeter J Bond
May 31, 2013·Journal of Integrative Plant Biology·Zhao Zhang, Bart P H J Thomma
Feb 15, 2015·Developmental and Comparative Immunology·Sergio CandelVictoriano Mulero
Jan 22, 2009·Cell Host & Microbe·Antje BlumenthalSabine Ehrt
Nov 12, 2015·PloS One·Nicole EgliTamas Schweighoffer
Oct 28, 2020·Cancer Immunology, Immunotherapy : CII·Ruishi ZhangGuohui Nie

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