The rs11515 Polymorphism Is More Frequent and Associated With Aggressive Breast Tumors with Increased ANRIL and Decreased p16 (INK4a) Expression

Frontiers in Oncology
Janice A RoydsTania L Slatter

Abstract

Chromosome position 9p21 encodes three-tumor suppressors p16(INK4a), p14(ARF), and p15(INK4b) and the long non-coding RNA ANRIL (antisense non-coding RNA in the INK4 locus). The rs11515 single-nucleotide polymorphism in the p16 (INK4a) /p14 (ARF) 3'-untranslated region is associated with glioblastoma, melanoma, and other cancers. This study investigated the frequency and effect of rs11515 genotypes in breast cancer. Genomic DNA samples from 400 women (200 with and 200 without a diagnosis of breast cancer) were genotyped for the rs11515 major (C) and minor (G) alleles. The rs11515 polymorphism was also investigated in 108 heart tissues to test for tissue-specific effects. Four 9p21 transcripts, p16 (INK4a) , p14 (ARF) , p15 (INK4b) , and ANRIL were measured in breast tumors and myocardium using quantitative PCR. Heterozygotes (CG genotype) were more frequent in women with breast cancer compared to the control population (P = 0.0039). In those with breast cancer, the CG genotype was associated with an older age (P = 0.016) and increased lymph node involvement (P = 0.007) compared to homozygotes for the major allele (CC genotype). In breast tumors, the CG genotype had higher ANRIL (P = 0.031) and lower p16 (INK4a) (P = 0.006) expr...Continue Reading

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Citations

Dec 15, 2017·Journal of Cellular Physiology·Mahdi RivandiAmir Avan
Sep 29, 2020·Future Oncology·Ning LouYunbao Pan
Jan 10, 2020·The Journal of Pathology. Clinical Research·Lucia CottoneAdrienne M Flanagan
Oct 2, 2019·Frontiers in Oncology·Paulomi M Mehta-MujooTania L Slatter

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Bio
Syngene GeneTools image
Rad Quantity One
SPSS
Lightcycler 480
SHEsis

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