The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth

The American Journal of Gastroenterology
Giuseppina R UmanoNicola Santoro

Abstract

Non alcoholic fatty liver disease (NAFLD) is a leading cause of liver damage in childhood, its occurrence is influenced by genetic and environmental factors. Recently, the rs626283 polymorphism in the MBOAT7 gene has been found to be associated with alcoholic liver disease and NAFLD in adults. In a multiethnic cohort of obese children and adolescents we genotyped the rs626283 polymorphism in the MBOAT7 gene, evaluated insulin sensitivity by an oral glucose tolerance test, and measured the intra-hepatic fat content (HFF%) by magnetic resonance imaging. In Caucasian youth, the minor allele (C) was associated with HFF% in (P=0.003), fasting insulin (P=0.03), area under the curve of glucose (P=0.03), and lower degree of whole-body insulin sensitivity (P=0.01) independent of age, gender, and body mass index z-score. A partial correlation showed that the association between the rs626283 variant and insulin resistance was driven by the presence of hepatic steatosis (P=0.009). However, there was no association between the rs626283 and hepatic steatosis among Hispanic and African American children and youth. The association between the rs626283 in the MBOAT7 gene among Caucasians was independent of the PNPLA3 rs738409, GCKR 1260326, and...Continue Reading

References

Jan 1, 1997·Magnetic Resonance Imaging·M H FishbeinM A Smith
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Catherine W YeckelSonia Caprio
Feb 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hyeonjin KimR Todd Constable
Sep 6, 2008·The Journal of Biological Chemistry·Miguel A GijónDennis R Voelker
May 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna M G CaliSonia Caprio
Jul 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca ValentiValerio Nobili
Aug 31, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola SantoroSonia Caprio
Oct 11, 2011·Pediatric Clinics of North America·Ebe D'AdamoSonia Caprio
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola SantoroSonia Caprio
Jan 31, 2014·The American Journal of Clinical Nutrition·Yu-Cheng LinYen-Hsuan Ni
Jun 27, 2014·World Journal of Gastroenterology : WJG·Pierluigi MarzuilloNicola Santoro
Jun 5, 2015·The Journal of Clinical Endocrinology and Metabolism·Nicola SantoroElizabeth J Parks
Oct 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Martina GoffredoNicola Santoro
Oct 27, 2015·World Journal of Gastroenterology : WJG·Fabio Salvatore MacalusoSalvatore Petta
Nov 2, 2016·Pediatric Research·Anna ViitasaloTimo A Lakka
Aug 2, 2016·JAMA Pediatrics·Kimberly P NewtonUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Aug 23, 2016·World Journal of Gastroenterology : WJG·Tyler J SeversonHerbert L Bonkovsky
Sep 16, 2016·Nature Communications·Khaled ThabetUNKNOWN International Liver Disease Genetics Consortium
Jan 22, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khaled ThabetMohammed Eslam

❮ Previous
Next ❯

Citations

Mar 16, 2019·Expert Review of Gastroenterology & Hepatology·Laura DraijerBart Koot
Apr 24, 2019·International Journal of Molecular Sciences·Simona MarchiselloAgata Maria Rabuazzo
Dec 19, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Aki Juhani KäräjämäkiOlavi Ukkola
Dec 4, 2019·Journal of Pediatric Gastroenterology and Nutrition·Anna Di SessaEmanuele Miraglia Del Giudice
Aug 21, 2019·Frontiers in Endocrinology·Ebe D'AdamoValerio Nobili
Jun 4, 2020·International Journal of Molecular Sciences·Hideki Fujii Japan Study Group Of Nafld Jsg-Nafld
Oct 27, 2020·Endocrinology, Diabetes & Metabolism·Federica TavaglioneStefano Romeo
Dec 29, 2020·Frontiers in Pediatrics·Yu-Cheng LinYen-Hsuan Ni
Feb 3, 2021·Clinical Therapeutics·Wei-Kei Wong, Wah-Kheong Chan
Feb 9, 2020·Gastroenterology Clinics of North America·Julia Kozlitina
Mar 24, 2020·Gastroenterology·Dana Goldner, Joel E Lavine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Martina GoffredoNicola Santoro
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Giovanni MussoRoberto Gambino
Liver International : Official Journal of the International Association for the Study of the Liver
L E WagenknechtCarl D Langefeld
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Khaled ThabetMohammed Eslam
© 2022 Meta ULC. All rights reserved