The Ruegeria pomeroyi acuI gene has a role in DMSP catabolism and resembles yhdH of E. coli and other bacteria in conferring resistance to acrylate.

PloS One
Jonathan D ToddAndrew W B Johnston

Abstract

The Escherichia coli YhdH polypeptide is in the MDR012 sub-group of medium chain reductase/dehydrogenases, but its biological function was unknown and no phenotypes of YhdH(-) mutants had been described. We found that an E. coli strain with an insertional mutation in yhdH was hyper-sensitive to inhibitory effects of acrylate, and, to a lesser extent, to those of 3-hydroxypropionate. Close homologues of YhdH occur in many Bacterial taxa and at least two animals. The acrylate sensitivity of YhdH(-) mutants was corrected by the corresponding, cloned homologues from several bacteria. One such homologue is acuI, which has a role in acrylate degradation in marine bacteria that catabolise dimethylsulfoniopropionate (DMSP) an abundant anti-stress compound made by marine phytoplankton. The acuI genes of such bacteria are often linked to ddd genes that encode enzymes that cleave DMSP into acrylate plus dimethyl sulfide (DMS), even though these are in different polypeptide families, in unrelated bacteria. Furthermore, most strains of Roseobacters, a clade of abundant marine bacteria, cleave DMSP into acrylate plus DMS, and can also demethylate it, using DMSP demethylase. In most Roseobacters, the corresponding gene, dmdA, lies immediately...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D H Figurski, D R Helinski
Jun 1, 1992·Computer Applications in the Biosciences : CABIOS·D T JonesJ M Thornton
Nov 25, 1989·Nucleic Acids Research·M A Alting-Mees, J M Short
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P M Rougraff, R Paxton
Jul 1, 1997·International Journal of Systematic Bacteriology·J M GonzalezW B Whitman
Sep 22, 2001·Journal of Biotechnology·I M López-Lara, O Geiger
Dec 26, 2001·Science·H C SeoD Chourrout
Jun 12, 2002·Journal of Bacteriology·John W Campbell, John E Cronan
Sep 18, 2003·International Journal of Systematic and Evolutionary Microbiology·José M GonzálezMary Ann Moran
Jun 8, 2004·Journal of Experimental Botany·Marinus L OtteBridget M Moran
Sep 25, 2004·Acta Crystallographica. Section D, Biological Crystallography·Gerlind SulzenbacherChristian Cambillau
Jan 27, 2005·The FEBS Journal·Gloria HerrmannWolfgang Buckel
Dec 1, 1991·Applied and Environmental Microbiology·B F Taylor, D C Gilchrist
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B J StaskawiczN T Keen
Apr 28, 2006·Genome Biology·J Peter W YoungJulian Parkhill
Oct 28, 2006·Science·Erinn C HowardMary Ann Moran
Oct 10, 2007·Environmental Microbiology·Helmut BürgmannMary Ann Moran
Feb 7, 2008·Archives of Microbiology·Thorsten BrinkhoffMeinhard Simon
Mar 14, 2008·Nature·H James TrippStephen J Giovannoni
Jul 22, 2008·Nature Chemical Biology·Andrew G Palmer, Helen E Blackwell
Jan 5, 2010·Trends in Microbiology·Jean-Baptiste RainaDavid G Bourne
Jan 15, 2010·The ISME Journal·Ryan J NewtonMary Ann Moran
May 25, 2010·Biochemical and Biophysical Research Communications·Hans JörnvallBengt Persson
Feb 10, 2011·Standards in Genomic Sciences·Amrita PatiNikos C Kyrpides

❮ Previous
Next ❯

Citations

Oct 4, 2014·The Journal of Microbiology·Paula SalgadoCatarina Magalhães
Nov 19, 2013·Nature Chemical Biology·Raoul G RosenthalTobias J Erb
Jan 20, 2016·Applied Microbiology and Biotechnology·Wenhua TongGuang Zhao
Jul 15, 2015·Nucleic Acids Research·Jameson K RogersGeorge M Church
Feb 24, 2015·The ISME Journal·Vanessa A VaraljayMary Ann Moran
Oct 31, 2018·Nature Chemical Biology·Iria BernhardsgrütterTobias J Erb
Jun 25, 2019·Science China. Life Sciences·Xiao-Hua ZhangJonathan D Todd
Jul 3, 2013·Molecular Microbiology·Chris R ReischWilliam B Whitman
Dec 23, 2015·Algorithms for Molecular Biology : AMB·Gabriel CardonaFrancesc Rosselló
Oct 28, 2016·Biotechnology and Bioengineering·Xianghao Wu, Mark A Eiteman
Jun 24, 2016·Environmental Microbiology Reports·Andrew S BurnsMary Ann Moran
Jan 1, 2014·Standards in Genomic Sciences·Adam R RiversMary Ann Moran
Jul 27, 2017·Journal of Industrial Microbiology & Biotechnology·Xianghao Wu, Mark A Eiteman
Jun 5, 2020·Biotechnology and Bioengineering·Xianghao WuMark A Eiteman
May 5, 2017·Frontiers in Microbiology·Hannah A BullockWilliam B Whitman
Jun 23, 2019·The ISME Journal·Marine LandaMary Ann Moran
Oct 25, 2020·The ISME Journal·Frank Xavier Ferrer-GonzálezMary Ann Moran
Apr 17, 2021·Biotechnology Letters·Aleksander S ReshetnikovValentina N Khmelenina

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

BIONJ
BLASTP

Related Concepts

Related Feeds

Bacterial Protein Structures

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.