The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

International Journal of Molecular Sciences
Xuekun FuGe Zhang

Abstract

Biological macromolecules are the basis of life activities. There is a separation of spatial dimension between DNA replication and RNA biogenesis, and protein synthesis, which is an interesting phenomenon. The former occurs in the cell nucleus, while the latter in the cytoplasm. The separation requires protein to transport across the nuclear envelope to realize a variety of biological functions. Nucleocytoplasmic transport of protein including import to the nucleus and export to the cytoplasm is a complicated process that requires involvement and interaction of many proteins. In recent years, many studies have found that proteins constantly shuttle between the cytoplasm and the nucleus. These shuttling proteins play a crucial role as transport carriers and signal transduction regulators within cells. In this review, we describe the mechanism of nucleocytoplasmic transport of shuttling proteins and summarize some important diseases related shuttling proteins.

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Citations

Jul 21, 2020·American Journal of Physiology. Renal Physiology·Zhiyong WangSteven C Borkan
Jul 4, 2020·Translational Neurodegeneration·Giacomo Bitetto, Alessio Di Fonzo
Sep 22, 2019·International Journal of Molecular Sciences·Cecilia MittelbergerKatrin Janik
Mar 12, 2020·Journal of Cancer Research and Clinical Oncology·Tilman L R VogelsangAurelia Vattai
Feb 6, 2019·Biomolecules·Nadia R ZgajnarMario D Galigniana
Apr 5, 2020·International Journal of Molecular Sciences·Elizabeth Ruiz-MárvezConcepción J Puerta
Oct 6, 2020·Cell Cycle·Alexandre Pj Martin, Jacques H Camonis
Dec 17, 2020·Development·Valeria GuglielmiMaximiliano A D'Angelo
Mar 9, 2021·Frontiers in Molecular Biosciences·Allegra MboukouPierre Barraud
May 24, 2021·Cell Communication and Signaling : CCS·Juane LuHaihua Ruan
Jul 28, 2021·Journal of Cell Science·Anna M DowbajErik Sahai
Aug 24, 2021·Trends in Endocrinology and Metabolism : TEM·Gisela I MazairaMario D Galigniana

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Methods Mentioned

BETA
GTPase
proximity ligation
biopsies

Software Mentioned

BioID

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