The Russell viper venom time (RVVT) test for investigation of lupus anticoagulant (LA)

American Journal of Hematology
Emmanuel Favaloro

Abstract

Lupus anticoagulants (LAs) are a laboratory representation of the clinical syndrome of antiphospholipid syndrome (APS), and can also arise in other pathological states. Laboratory testing for LA is complex and three separate recent guidelines have been published. One test, the Russell viper venom time (RVVT), is the mandated laboratory test for inclusion in LA identification/exclusion in all three guidance documents. This is because the the RVVT is recognized to have great sensitivity for LA, with this generally recognized to be greater than that of most other LA screening assays. However, the RVVT is also very sensitive to the presence of many anticoagulant drugs, which diminishes its specificity for LA. Various strategies can be used to improve LA specificity and reduce anticoagulant assay interference.

References

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Citations

Apr 21, 2020·American Journal of Hematology·Gary W Moore
Jun 17, 2020·International Journal of Laboratory Hematology·Thomas ExnerEmmanuel J Favaloro
May 30, 2020·British Journal of Hospital Medicine·Stephen BoothMichael Desborough
Jul 15, 2021·Seminars in Thrombosis and Hemostasis·Gábor SzabóJános Kappelmayer
Jul 17, 2021·Clinical Journal of Oncology Nursing·Jace D Johnny
Sep 28, 2021·Journal of Medicinal Chemistry·Upasana PuzariAshis K Mukherjee

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