PMID: 11309147Apr 20, 2001Paper

The S-methylmethionine cycle in angiosperms: ubiquity, antiquity and activity

The Plant Journal : for Cell and Molecular Biology
Philippe RanochaA D Hanson

Abstract

Angiosperms synthesize S-methylmethionine (SMM) from methionine (Met) and S-adenosylmethionine (AdoMet) in a unique reaction catalyzed by Met S-methyltransferase (MMT). SMM serves as methyl donor for Met synthesis from homocysteine, catalyzed by homocysteine S-methyltransferase (HMT). MMT and HMT together have been proposed to constitute a futile SMM cycle that stops the free Met pool from being depleted by an overshoot in AdoMet synthesis. Arabidopsis and maize have one MMT gene, and at least three HMT genes that belong to two anciently diverged classes and encode enzymes with distinct properties and expression patterns. SMM, and presumably its cycle, must therefore have originated before dicot and monocot lineages separated. Arabidopsis leaves, roots and developing seeds all express MMT and HMTs, and can metabolize [35S]Met to [35S]SMM and vice versa. The SMM cycle therefore operates throughout the plant. This appears to be a general feature of angiosperms, as digital gene expression profiles show that MMT and HMT are co-expressed in leaves, roots and reproductive tissues of maize and other species. An in silico model of the SMM cycle in mature Arabidopsis leaves was developed from radiotracer kinetic measurements and pool si...Continue Reading

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Citations

Nov 15, 2008·Amino Acids·David H Baker
Nov 25, 2005·Photosynthesis Research·Markus Wirtz, Michel Droux
Oct 2, 2002·Physiologia Plantarum·Karine GallardoDominique Job
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Fabrice RébeilléStéphane Ravanel
Aug 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yukako ChibaSatoshi Naito
Dec 6, 2011·Annual Review of Plant Biology·Loïc RajjouDominique Job
Dec 26, 2012·Plant Physiology and Biochemistry : PPB·Magdalena Arasimowicz-JelonekJagna Chmielowska-Bąk
Jan 23, 2008·The Plant Journal : for Cell and Molecular Biology·Minsang LeeGeorg Jander
Jul 10, 2007·The Plant Journal : for Cell and Molecular Biology·Yael HachamRachel Amir
Apr 21, 2006·The Plant Journal : for Cell and Molecular Biology·Heather CoinerJoachim Schröder
Apr 11, 2012·The Plant Journal : for Cell and Molecular Biology·Johannes ThielHans Weber
May 28, 2011·The Plant Journal : for Cell and Molecular Biology·Daniel M HaydenKatayoon Dehesh
Oct 18, 2005·Trends in Plant Science·Robert C SchuurinkDavid G Clark
Jul 22, 2014·The Biochemical Journal·Louis M T BradburyAndrew D Hanson
Jan 7, 2016·Annual Review of Plant Biology·Gad GaliliAlisdair R Fernie
Nov 9, 2016·Frontiers in Plant Science·Jianwei GuMaoteng Li
Apr 21, 2018·International Journal of Molecular Sciences·Man ZhaoXiangxian Ying
Feb 6, 2018·Plant Reproduction·Wenyi WangGad Galili
Aug 18, 2017·Physiologia Plantarum·Moona RahikainenSaijaliisa Kangasjärvi

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