The S2 accessory gene of equine infectious anemia virus is essential for expression of disease in ponies

Virology
Angela FagernessF J Fuller

Abstract

Equine infectious anemia virus (EIAV) is a macrophage-tropic lentivirus that persistently infects horses and causes a disease that is characterized by periodic episodes of fever, thrombocytopenia, and viremia. EIAV encodes only four regulatory/accessory genes, (tat, rev, ttm, and S2) and is the least genetically complex of all known lentiviruses. We sought to determine the role of the EIAV S2 accessory gene of EIAV by introducing mutations that would prevent S2 expression on the p19/wenv17 infectious molecular clone. Virus derived from the p19/wenv17 molecular clone is highly virulent and routinely fatal when given in high doses (J. Virol. 72 (1998) 483). In contrast, an S2 deletion mutant on the p19/wenv17 background is unable to induce acute disease and plasma virus loads were reduced by 2.5 to 4.0 logs at 15 days post-infection. The S2 deleted virus failed to produce any detectable clinical signs during a 5-month observation period. These results demonstrate that S2 gene expression is essential for disease expression of EIAV.

References

Jan 1, 1988·Annual Review of Biochemistry·D A TowlerL Glaser
Jan 1, 1973·Archiv für die gesamte Virusforschung·Y KonoY Fukunaga
Sep 16, 2004·Journal of Virology·Michael SchindlerFrank Kirchhoff

❮ Previous
Next ❯

Citations

May 22, 2009·Journal of Virology·Jörg ZielonkaCarsten Münk
Jun 3, 2015·Retrovirology·Jongsu ChoiKwangseog Ahn
Apr 21, 2001·BMC Blood Disorders·Rafael NunezKarsten Feige
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ajit ChandeMassimo Pizzato
Jan 24, 2018·Journal of Immunology Research·Gracia Viviana Gonzalez-EnriquezBlanca Miriam Torres-Mendoza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.