PMID: 8972872Dec 1, 1996Paper

The Saccharomyces retrotransposon Ty5 influences the organization of chromosome ends

Nucleic Acids Research
S ZouD F Voytas

Abstract

Retrotransposons are ubiquitous components of eukaryotic genomes suggesting that they have played a significant role in genome organization. In Saccharomyces cerevisiae, eight of 10 endogenous insertions of the Ty5 retrotransposon family are located within 15 kb of chromosome ends, and two are located near the subtelomeric HMR locus. This genomic organization is the consequence of targeted transposition, as 14 of 15 newly transposed Ty5 elements map to telomeric regions on 10 different chromosomes. Nine of these insertions are within 0.8 kb and three are within 1.5 kb of the autonomously replicating consensus sequence in the subtelomeric X repeat. This suggests that the X repeat plays an important role in directing Ty5 integration. Analysis of endogenous insertions from S.cerevisiae and its close relative S.paradoxus revealed that only one of 12 insertions has target site duplications, indicating that recombination occurs between elements. This is further supported by the observation that Ty5 insertions mark boundaries of sequence duplications and rearrangements in these species. These data suggest that transposable elements like Ty5 can shape the organization of chromosome ends through both transposition and recombination.

References

Aug 27, 1992·Nature·D F Voytas, J D Boeke
Jan 1, 1992·Annual Review of Biochemistry·E H Blackburn
May 7, 1992·Nature·S G OliverP Benit
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jul 12, 1984·Nature·J ShampayE H Blackburn
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Dec 8, 1995·Science·V A Zakian
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·S ZouD F Voytas
Jun 2, 1994·Nature·B DujonP Bossier

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Citations

Feb 20, 1998·Current Opinion in Genetics & Development·F E PrydeE J Louis
Jun 4, 1998·Current Opinion in Genetics & Development·A J Lustig
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Joshua A BallerDaniel F Voytas
May 3, 2000·Genome Génome / Conseil National De Recherches Canada·M Horáková, J Fajkus
Aug 12, 2005·Cytogenetic and Genome Research·P Lesage, A L Todeschini
Mar 19, 2011·Biology Direct·Aurélie Hua-VanPierre Capy
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Zou, D F Voytas
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yunxia ZhuDaniel F Voytas
Mar 14, 2017·Nature Reviews. Genetics·Tania SultanaPascale Lesage
May 2, 2018·Mobile DNA·Stephanie CheungVivien Measday
Mar 11, 2020·Trends in Genetics : TIG·Bastien Saint-Leandre, Mia T Levine
Feb 15, 2000·Genome Research·T J Goodwin, R T Poulter

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