The safety and clinical usefulness of dobutamine stress echocardiography among octogenarians

Jamie M O'DriscollRajan Sharma


Increasing numbers of octogenarians are being referred for investigation of chest pain. While dobutamine stress echocardiography (DSE) has been shown to be useful in younger patients, its role among octogenarians remains unclear. This investigation aimed to investigate the safety and prognostic benefits of DSE on cardiac events and total mortality in octogenarians. 550 consecutive patients aged ≥80 years underwent DSE for suspected cardiac chest pain. All subjects were followed-up prospectively until March 2011, and the study end-points were a major cardiac event and total mortality. One hundred and eighty-three (33%) patients had a positive DSE result, 271 (49%) had a normal study, and 164 (30%) had fixed-wall motion abnormalities. During a mean follow-up of 2.14±1.13 years, there were 217 (39%) cardiac events and 63 (11%) deaths, of which 46 (73%) were cardiac. The absolute risk of cardiac events increased with burden of ischaemia on DSE, from 13%/year (none), to 26%/year (1-3 ischaemic (LV) segments), and 38%/year (>3 ischaemic LV segments), p<0.001. Any ischaemia was associated with an additional 13 cardiac events per 100 person-years. In multivariate analysis, compared with non-ischaemic patients, the relative hazard of ca...Continue Reading


Mar 1, 1983·The Medical Clinics of North America·R Harris
Feb 1, 1993·American Journal of Epidemiology·M B MittelmarkD H O'Leary
Dec 3, 1999·European Heart Journal·J KählerC W Hamm
Nov 12, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elena BiaginiDon Poldermans
Mar 28, 2007·The New England Journal of Medicine·William E BodenUNKNOWN COURAGE Trial Research Group
May 30, 2007·Archives of Internal Medicine·Finlay A McAlisterUNKNOWN Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators
Sep 5, 2007·Echocardiography·Farooq A ChaudhrySripal Bangalore
Jul 1, 2010·The International Journal of Cardiovascular Imaging·Francesca InnocentiRiccardo Pini
Nov 19, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Satoshi YanagisawaToshikazu Tanaka
Apr 9, 2011·American Heart Journal·Alain M BernheimPatricia A Pellikka
Jul 17, 2012·The American Journal of Cardiology·Mridula RaiGary Vashon Heller

❮ Previous
Next ❯


Sep 14, 2014·Progress in Cardiovascular Diseases·Nidhi MehtaJames N Kirkpatrick

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē
Stella V BriliChristodoulos Stefanadis
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Elena BiaginiDon Poldermans
© 2022 Meta ULC. All rights reserved