The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study.

Journal of Psychopharmacology
Michael C MithoeferRick Doblin

Abstract

Case reports indicate that psychiatrists administered ±3,4-methylenedioxymethamphetamine (MDMA) as a catalyst to psychotherapy before recreational use of MDMA as 'Ecstasy' resulted in its criminalization in 1985. Over two decades later, this study is the first completed clinical trial evaluating MDMA as a therapeutic adjunct. Twenty patients with chronic posttraumatic stress disorder, refractory to both psychotherapy and psychopharmacology, were randomly assigned to psychotherapy with concomitant active drug (n = 12) or inactive placebo (n = 8) administered during two 8-h experimental psychotherapy sessions. Both groups received preparatory and follow-up non-drug psychotherapy. The primary outcome measure was the Clinician-Administered PTSD Scale, administered at baseline, 4 days after each experimental session, and 2 months after the second session. Neurocognitive testing, blood pressure, and temperature monitoring were performed. After 2-month follow-up, placebo subjects were offered the option to re-enroll in the experimental procedure with open-label MDMA. Decrease in Clinician-Administered PTSD Scale scores from baseline was significantly greater for the group that received MDMA than for the placebo group at all three time...Continue Reading

References

Apr 1, 1977·Perceptual and Motor Skills·D M Gronwall
May 1, 1992·The American Journal of Psychiatry·N Breslau, G C Davis
Jan 1, 1986·Psychological Bulletin·E B Foa, M J Kozak
Aug 27, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F X VollenweiderT Huber
Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·C RandolphT N Chase
Jan 30, 1999·Journal of Psychoactive Drugs·G R Greer, R Tolbert
Apr 6, 1999·Journal of Child Psychology and Psychiatry, and Allied Disciplines·A A Thabet, P Vostanis
Mar 25, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E LiechtiF X Vollenweider
Apr 19, 2000·JAMA : the Journal of the American Medical Association·K BradyG M Farfel
Sep 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A GammaD Hell
Apr 21, 2001·Psychopharmacology·M E LiechtiF X Vollenweider
Jun 5, 2001·Depression and Anxiety·F W WeathersJ R Davidson
Nov 21, 2001·Drug and Alcohol Dependence·M E Tancer, C E Johanson
Dec 1, 2001·The American Journal of Psychiatry·R D MarshallR Zaninelli
Aug 13, 2002·Psychopharmacology·Debra S HarrisReese T Jones
Jun 27, 2003·Lancet·Joop T V M de JongMark Van Ommeren
Dec 24, 2003·Journal of Traumatic Stress·Elizabeth A HembreeXin Tu
Jan 2, 2004·The American Journal of Psychiatry·Mark S Bauer, Landis Mitchner
Jul 1, 2004·Archives of Internal Medicine·Susan M FrayneKatherine M Skinner
Jul 2, 2004·The New England Journal of Medicine·Charles W HogeRobert L Koffman
Jun 3, 2005·Nature·Michael KosfeldErnst Fehr
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Aug 20, 2005·Hormones and Behavior·Paul J ZakWilliam T Matzner
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter KirschAndreas Meyer-Lindenberg
Jan 7, 2006·Der Nervenarzt·U Benzenhöfer, T Passie
Apr 1, 2006·Journal of Psychopharmacology·Kim WolffKatherine J Aitchison
Aug 17, 2006·Addiction·Roland W FreudenmannSabine Bernschneider-Reif
Nov 1, 2006·Journal of Traumatic Stress·Michael DavisStephen Southwick
Nov 1, 2006·Journal of Traumatic Stress·Barbara O RothbaumChang-Gyu Hahn
Dec 2, 2006·Biological Psychiatry·Gregor DomesSabine C Herpertz
Sep 25, 2007·The Journal of Pharmacology and Experimental Therapeutics·Magí FarréRafael de la Torre
Aug 6, 2009·JAMA : the Journal of the American Medical Association·Beth E CohenKaren H Seal

❮ Previous
Next ❯

Citations

Jan 27, 2012·Psychopharmacology·Cédric M HysekMatthias E Liechti
Oct 8, 2013·Social Cognitive and Affective Neuroscience·Cédric M HysekMatthias E Liechti
Oct 22, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marta ConcheiroMarilyn A Huestis
Oct 23, 2013·European Journal of Psychotraumatology·Rianne A de KleineAgnes van Minnen
Aug 12, 2014·Health Technology Assessment : HTA·Samantha BartonSteven J Edwards
Apr 15, 2014·Psychopharmacology·Margaret C Wardle, Harriet de Wit
Jun 11, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bjørnar den HollanderEsko Kankuri
Jun 2, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·J L OeiM E Abdel-Latif
Jan 21, 2016·Social Neuroscience·Anya K BershadHarriet de Wit
Nov 12, 2013·Expert Opinion on Drug Discovery·Adam Michael Stewart, Allan V Kalueff
Jul 28, 2012·Expert Opinion on Investigational Drugs·Christopher K CainJohn H Kehne
Feb 9, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ralph J KoekAndrew Leuchter
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Jan 10, 2016·Neuroscience and Biobehavioral Reviews·F MuellerS Borgwardt
Mar 26, 2013·Journal of the American College of Surgeons·Lewis Flint
Sep 16, 2015·Aquatic Toxicology·Allan V KalueffUNKNOWN International Zebrafish Neuroscience Research Consortium ZNRC
Sep 27, 2015·Neuroscience and Biobehavioral Reviews·Philip Kamilar-Britt, Gillinder Bedi
Jul 7, 2012·Drug Testing and Analysis·Simon D Brandt, Torsten Passie
Mar 1, 2012·Drug Testing and Analysis·Daniel Trachsel
Nov 7, 2015·BioMed Research International·Débora GonzálezMagí Farré
Jun 16, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Magí FarréRafael de la Torre
Apr 14, 2016·The Lancet. Psychiatry·Michael C MithoeferTimothy D Brewerton
Sep 16, 2015·Translational Psychiatry·M B YoungL L Howell
Apr 29, 2015·Journal of Neuroendocrinology·Gül Dölen
Mar 31, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alicia L DanforthCharles S Grob
Apr 11, 2012·Pharmacology, Biochemistry, and Behavior·Adam L HalberstadtMark A Geyer
Nov 28, 2012·European Journal of Pharmacology·Nicholas V CozziMichael H Baumann
Aug 24, 2013·The American Journal of Drug and Alcohol Abuse·Brittany Vasae Burdick, Bryon Adinoff
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugene A KiyatkinYavin Shaham
May 3, 2015·The British Journal of Psychiatry : the Journal of Mental Science·Rani Pathania

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.