The safety and efficacy of gemcitabine for the treatment of bladder cancer

Expert Review of Anticancer Therapy
Katrin SchlackLaura-Maria Krabbe

Abstract

Bladder cancer is a common type of cancer with an estimated incidence of more than 70,000 patients and had a mortality of 16,000 patients in the US in 2015. In more than 70% of cases the disease is diagnosed at the non-muscle invasive stage. However, muscle invasive or metastatic stages need multimodal treatment strategies including surgical treatment and chemotherapy in a neoadjuvant, adjuvant or palliative setting. Gemcitabine is a pyrimidine antimetabolite that has shown efficacy when used systemically in bladder cancer with only mild toxicity compared to other chemotherapeutic agents. This article aims to summarize the results of clinical trials in monotherapeutic, combined or sequential treatment strategies, especially considering efficacy and safety of the different therapeutic regimes.

References

Feb 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C F PolleraF Calabresi
Nov 18, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M StadlerF A Dorr
May 23, 1998·Advances in Experimental Medicine and Biology·C J van MoorselG J Peters
Mar 29, 2000·BJU International·C N Sternberg, F Calabrò
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A MeluchJ D Hainsworth
Aug 29, 2003·The New England Journal of Medicine·H Barton GrossmanE David Crawford
Jan 18, 2006·International Journal of Clinical Practice·G FechnerUNKNOWN German Association Of Urologic Oncology (Auo) Bladder Cancer Study Group
Jul 29, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H von der MaaseM Kania
Aug 19, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J CarlesUNKNOWN Spanish Oncology Genito Urinary Group Study Group
Nov 6, 2007·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Daniel HerchenhornCarlos G Ferreira
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew I MilowskyDean F Bajorin
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Noah M HahnUNKNOWN Hoosier Oncology Group
Dec 18, 2012·American Journal of Clinical Oncology·Uzair B ChaudharyVinay Gudena
Jan 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arjun V BalarDean F Bajorin
Apr 16, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Peter E ClarkUNKNOWN National Comprehensive Cancer Network (NCCN)
May 3, 2013·Cancer Chemotherapy and Pharmacology·Zeynep Eroglu, John P Fruehauf
Jun 4, 2013·The New England Journal of Medicine·Jedd D WolchokMario Sznol
Jul 6, 2013·European Urology·Marko BabjukUNKNOWN European Association of Urology
Aug 2, 2014·European Journal of Pharmacology·Lucas de Sousa Cavalcante, Gisele Monteiro

❮ Previous
Next ❯

Citations

Jun 4, 2019·Frontiers in Pharmacology·Svetlana Miroshnichenko, Olga Patutina
Jul 2, 2020·Biomedicines·Nobutomo IkarashiKiyoshi Sugiyama
Jun 18, 2021·Frontiers in Cell and Developmental Biology·Zhenyu NieShufang Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Oncology : Official Journal of the European Society for Medical Oncology
G D'AuriaE Cortesi
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Jung Hwan KimHyo-Jin Kim
Annals of Oncology : Official Journal of the European Society for Medical Oncology
Cora N Sternberg
© 2022 Meta ULC. All rights reserved