The safety and efficacy of subcutaneous birch pollen immunotherapy - a one-year, randomised, double-blind, placebo-controlled study

Allergy
Uffe BødtgerH J Malling

Abstract

There is only very limited documentation of the efficacy and safety of high-dose subcutaneous birch pollen immunotherapy (IT) in double-blind, placebo-controlled (DBPC) studies. Birch pollen is a major cause of allergic morbidity in northern Europe and in eastern parts of North America. Thirty-five patients with severe rhinoconjunctivitis (hay fever) to birch pollen were allocated to double-blinded clustered IT with a depot birch pollen extract (Betula verrucosa) or placebo injections. Seven patients in each group had concomitant self-reported seasonal asthma. Treatment was conducted as a clustered regimen and was performed in a specialist unit. Symptom scores from nose, eyes, and lungs, and use of oral and topical antihistamines, beta-2-agonists, and oral corticosteroids were recorded daily during the season of 2000. Sensitivity to allergen provocation in skin, conjunctiva, and nasal mucosa was measured before and after 10 months of treatment. Post-seasonal assessment of symptom severity was performed using a simple questionnaire. IT reduced the symptom score for both rhinoconjunctivitis and asthma (P-values < 0.05), total medication score (P < 0.02) and use of oral antihistamines (P < 0.01). IT reduced specific conjunctival s...Continue Reading

References

Nov 1, 1990·The Journal of Allergy and Clinical Immunology·S RakP Venge
Dec 1, 1985·The Journal of Clinical Investigation·P S CreticosP S Norman
Jan 1, 1988·International Archives of Allergy and Applied Immunology·E Taudorf, L Moseholm
Apr 1, 1987·The Journal of Allergy and Clinical Immunology·R F LockeyS C Bukantz
Jan 1, 1984·Allergy·C MöllerS Dreborg
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G D'AmatoL L Freshwater
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·J BousquetF B Michel
Jul 1, 1993·The Journal of Allergy and Clinical Immunology·M J ReidT A Platts-Mills
Jan 1, 1993·Allergy
Feb 22, 1996·The New England Journal of Medicine·P S CreticosJ T Li
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H H JacobiN Mygind
Feb 26, 1999·BMJ : British Medical Journal·P G ShekelleJ Grimshaw
Apr 13, 1999·The Journal of Allergy and Clinical Immunology·G HedlinH Lowenstein
Aug 19, 1999·The Journal of Allergy and Clinical Immunology·E F JuniperJ N Roberts
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M S Blaiss
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·S M WalkerS R Durham
Sep 12, 2001·Allergy·S G JohanssonUNKNOWN EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force

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Citations

Mar 29, 2003·Current Allergy and Asthma Reports·Hans-Jørgen Malling
Nov 9, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C GlueL K Poulsen
Mar 3, 2005·International Archives of Allergy and Immunology·U BodtgerM Svenson
Mar 8, 2014·Revue des maladies respiratoires·F LavaudF de Blay
Nov 5, 2013·Auris, Nasus, Larynx·Yoshitaka OkamotoShigeharu Fujieda
Aug 13, 2011·International Archives of Allergy and Immunology·Marina MauroGianni Passalacqua
Oct 29, 2010·Current Medical Research and Opinion·Linda Cox, Moises A Calderon
Jul 9, 2011·Immunology and Allergy Clinics of North America·Linda Cox, Dana Wallace
May 31, 2011·The Journal of Allergy and Clinical Immunology·Paolo Maria MatricardiAnnemie Narkus
Oct 6, 2007·The Journal of Allergy and Clinical Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Apr 10, 2007·The Journal of Allergy and Clinical Immunology·Giovanni PassalacquaUNKNOWN Global Allergy and Asthma European Network
Dec 15, 2006·The Journal of Allergy and Clinical Immunology·Ronald van Ree
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MironeC Ortolani
Feb 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C G JakobsenE L Roggen
Jan 25, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H PlewakoS Rak
Apr 12, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U BodtgerH-J Malling
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G B PajnoG Barberio
Jun 20, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A PurohitO Cromwell
Aug 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ko-Huang LueMing-Chih Chou
Jul 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A-S HöibyS Rak
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M ZidarnP Korošec
Jun 10, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N LalekP Korosec
Jan 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Passalacqua, G W Canonica
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Uffe Bodtger, Allan Linneberg
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·Uffe BodtgerLars K Poulsen
May 4, 2016·Immunotherapy·Philippe MoingeonLaurent Mascarell
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Margitta WormMark Larché
Dec 21, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Margitta WormErkka Valovirta
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M A CalderonS Durham
Jan 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian MöbsWolfgang Pfützner
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Michael J AbramsonJohn M Weiner
Jul 15, 2015·Asthma Research and Practice·Giovanni PassalacquaGiorgio Walter Canonica
Sep 7, 2013·Advances in Pediatrics·Kenny Y Kwong, Sydney Leibel

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