The safety and immunogenicity of an inactivated SARS-CoV-2 vaccine in Chinese adults aged 18-59 years: A phase I randomized, double-blinded, controlled trial.

Vaccine
Jing PuQihan Li

Abstract

This study examined the safety and immunogenicity of an inactivated SARS-CoV-2 vaccine. In a phase I randomized, double-blinded, placebo-controlled trial involving 192 healthy adults 18-59 years old, two injections of three doses (50 EU, 100 EU, 150 EU) of an inactivated SARS-CoV-2 vaccine or placebo were administered intramuscularly at a 2- or 4-week interval. The safety and immunogenicity of the vaccine were evaluated. Vaccination was completed in 191 subjects. Forty-four adverse reactions occurred within 28 days, most commonly mild pain and redness at the injection site or slight fatigue. At days 14 and 28, the seroconversion rates were 87.5% and 79.2% (50 EU), 100% and 95.8% (100 EU), and 95.8% and 87.5% (150 EU), respectively, with geometric mean titers (GMTs) of 18.1 and 10.6, 54.5 and 15.4, and 37.1 and 18.5, respectively, for the schedules with 2-week and 4-week intervals. Seroconversion was associated with synchronous upregulation of antibodies against the S protein, N protein and virion and a cytotoxic T lymphocyte (CTL) response. No cytokines and immune cells related to immunopathology were observed. Transcriptome analysis revealed the genetic diversity of immune responses induced by the vaccine. In a population aged...Continue Reading

References

Dec 19, 2014·PLoS Neglected Tropical Diseases·Erik AlmNina Lagerqvist
Mar 25, 2020·Revista clínica española·M Palacios CruzM León Juárez
Mar 27, 2020·Pathogens·Saif Ur RehmanQingyou Liu
Apr 19, 2020·Turkish Journal of Medical Sciences·Tuğba Bedir Demirdağ, Hasan Tezer
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Aug 1, 2020·Journal of Critical Care·Fang-Fang ChenYun Zhang
Aug 4, 2020·BioRxiv : the Preprint Server for Biology·Junko OgawaGerald M Pao
Aug 14, 2020·Nature·Mark J MulliganKathrin U Jansen
Aug 14, 2020·JAMA : the Journal of the American Medical Association·Shengli XiaXiaoming Yang

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