The safety and persistence of non-vitamin-K-antagonist oral anticoagulants in atrial fibrillation patients treated in a well structured atrial fibrillation clinic

Current Medical Research and Opinion
Faris Al-KhaliliLina Benson

Abstract

To examine the long-term persistence and safety of the non-vitamin-K-antagonist oral anticoagulants (NOACs) dabigatran (D), rivaroxaban (R) and apixaban (A) in patients with non-valvular atrial fibrillation (AF) treated in the framework of a well structured, nurse-based AF unit for initiation and follow-up of NOAC. Retrospective clinical data were collected for 766 consequent patients from a single cardiology outpatient clinic incorporating the AF unit. The follow-up time, median (q1-q3), was 367 days (183-493) for D patients (n = 233), 432 days (255-546) for R patients (n = 282) and 348 days (267-419) for A patients (n = 251). No significant differences were found between the three groups with regard to age, sex, renal function, or CHA2DS2-VASc score. For all bleeding events the incidence rates per 100 patient-years of follow-up (95% confidence interval [CI], p-value) were reported more often for treatment with R (17.2, 12.7-22.8) than for D (7.0, 4.0-11.3, p = 0.001) and A (8.7, 5.2-13.6, p = 0.013). The differences remained significant after adjustment for clinically relevant variables. Discontinuation rates (n = 167) were lower for A (11.5, 7.5-16.8) than for D (30, 23.4-37.9, p < 0.001) and R (23.9, 18.6-30.1, p = 0.001), ...Continue Reading

References

Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Apr 9, 2013·Journal of the American College of Cardiology·Torben Bjerregaard LarsenGregory Y H Lip
Sep 2, 2014·European Heart Journal·A John Camm, Irina Savelieva
Nov 5, 2014·JAMA Internal Medicine·Inmaculada HernandezYuting Zhang
Feb 20, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan Beyer-WestendorfNorbert Weiss

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Citations

Jan 31, 2017·International Journal of Cardiology·Maria Cristina VedovatiCecilia Becattini
Jul 6, 2017·Expert Opinion on Drug Safety·José Miguel Rivera-CaravacaGregory Y H Lip
Nov 24, 2017·Stroke; a Journal of Cerebral Circulation·Marco ProiettiGregory Y H Lip
Sep 28, 2018·Expert Opinion on Drug Safety·Paolo VerdecchiaGiancarlo Agnelli
Oct 3, 2018·Expert Opinion on Drug Metabolism & Toxicology·Ylenia IngrasciottaGianluca Trifirò
May 2, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Géric MauraAntoine Pariente
Nov 18, 2017·European Journal of Clinical Pharmacology·Anne Katrine EekAnne Gerd Granas
Feb 6, 2020·Current Medical Research and Opinion·Darko MitrovicEric van Roon
Jan 26, 2021·European Heart Journal. Cardiovascular Pharmacotherapy·Danilo MenichelliDaniele Pastori
Feb 6, 2021·British Journal of Clinical Pharmacology·Mirjam HempeniusHelga Gardarsdottir
Nov 2, 2020·Journal of Thrombosis and Thrombolysis·Emmanouela KampourakiFarhad Kamali
Aug 6, 2021·British Journal of Clinical Pharmacology·Adane Teshome KefaleLuke R Bereznicki

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