Abstract
To examine the long-term persistence and safety of the non-vitamin-K-antagonist oral anticoagulants (NOACs) dabigatran (D), rivaroxaban (R) and apixaban (A) in patients with non-valvular atrial fibrillation (AF) treated in the framework of a well structured, nurse-based AF unit for initiation and follow-up of NOAC. Retrospective clinical data were collected for 766 consequent patients from a single cardiology outpatient clinic incorporating the AF unit. The follow-up time, median (q1-q3), was 367 days (183-493) for D patients (n = 233), 432 days (255-546) for R patients (n = 282) and 348 days (267-419) for A patients (n = 251). No significant differences were found between the three groups with regard to age, sex, renal function, or CHA2DS2-VASc score. For all bleeding events the incidence rates per 100 patient-years of follow-up (95% confidence interval [CI], p-value) were reported more often for treatment with R (17.2, 12.7-22.8) than for D (7.0, 4.0-11.3, p = 0.001) and A (8.7, 5.2-13.6, p = 0.013). The differences remained significant after adjustment for clinically relevant variables. Discontinuation rates (n = 167) were lower for A (11.5, 7.5-16.8) than for D (30, 23.4-37.9, p < 0.001) and R (23.9, 18.6-30.1, p = 0.001), ...Continue Reading
References
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Aug 30, 2011·European Heart Journal·Keith A A FoxRobert M Califf
Aug 15, 2012·Circulation·Deirdre A Lane, Gregory Y H Lip
Aug 31, 2012·European Heart Journal·Stefan H HohnloserLars Wallentin
Apr 9, 2013·Journal of the American College of Cardiology·Torben Bjerregaard LarsenGregory Y H Lip
Apr 30, 2013·European Heart Journal·Hein HeidbuchelPaulus Kirchhof
Dec 11, 2013·Circulation·Ziad HijaziLars Wallentin
May 27, 2014·Blood·Jan Beyer-WestendorfNorbert Weiss
Sep 2, 2014·European Heart Journal·A John Camm, Irina Savelieva
Nov 2, 2014·Circulation·David J GrahamJeffrey A Kelman
Nov 5, 2014·JAMA Internal Medicine·Inmaculada HernandezYuting Zhang
Jan 16, 2015·Clinical Cardiology·Sally TamayoZhong Yuan
Feb 20, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan Beyer-WestendorfNorbert Weiss
Mar 6, 2015·Thrombosis and Haemostasis·Jan Beyer-WestendorfNorbert Weiss
Aug 4, 2015·International Journal of Clinical Practice·S I LeeD A Lane
Citations
Nov 11, 2016·Thrombosis and Haemostasis·Valeria RaparelliStefania Basili
Sep 3, 2016·Heart·Shweta SahayCarlos Macaya
Jan 31, 2017·International Journal of Cardiology·Maria Cristina VedovatiCecilia Becattini
Jul 6, 2017·Expert Opinion on Drug Safety·José Miguel Rivera-CaravacaGregory Y H Lip
Nov 24, 2017·Stroke; a Journal of Cerebral Circulation·Marco ProiettiGregory Y H Lip
Sep 28, 2018·Expert Opinion on Drug Safety·Paolo VerdecchiaGiancarlo Agnelli
Oct 3, 2018·Expert Opinion on Drug Metabolism & Toxicology·Ylenia IngrasciottaGianluca Trifirò
Apr 26, 2018·Thrombosis Journal·J M van den HeuvelA H Maitland-van der Zee
Oct 4, 2019·Expert Opinion on Drug Safety·Jakub GumprechtGregory Yh Lip
Sep 2, 2017·Current Medical Research and Opinion·Siyang PengAnuraag R Kansal
Mar 22, 2018·European Heart Journal·Jan SteffelUNKNOWN ESC Scientific Document Group
Jul 9, 2020·European Stroke Journal·Antonia MentelAzmil H Abdul-Rahim
May 2, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Géric MauraAntoine Pariente
Jun 28, 2018·European Journal of Epidemiology·Guowei LiMitchell A H Levine
Nov 18, 2017·European Journal of Clinical Pharmacology·Anne Katrine EekAnne Gerd Granas
Feb 6, 2020·Current Medical Research and Opinion·Darko MitrovicEric van Roon
Jan 26, 2021·European Heart Journal. Cardiovascular Pharmacotherapy·Danilo MenichelliDaniele Pastori
Feb 3, 2021·BMJ Open·Eveline M BungeAlexander Cohen
Feb 6, 2021·British Journal of Clinical Pharmacology·Mirjam HempeniusHelga Gardarsdottir
Aug 29, 2017·The American Journal of Cardiology·Ying BaiGregory Y H Lip
Apr 4, 2021·Pharmaceuticals·Ylenia IngrasciottaGianluca Trifirò
Mar 10, 2021·Current Medical Research and Opinion·Steven DeitelzweigJoseph C Cappelleri
Nov 2, 2020·Journal of Thrombosis and Thrombolysis·Emmanouela KampourakiFarhad Kamali
Jul 17, 2021·Journal of Clinical Epidemiology·Hao MeiShuangge Ma
May 17, 2021·European Journal of Epidemiology·Junguo ZhangGregory Y H Lip
Aug 6, 2021·British Journal of Clinical Pharmacology·Adane Teshome KefaleLuke R Bereznicki