The safety of β-carotene from Yarrowia lipolytica

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Daniel Grenfell-LeeKresimir Pucaj

Abstract

Crystalline β-carotene from genetically modified Yarrowia lipolytica is an alternative source of β-carotene for use as a nutritional supplement. To support the use of β-carotene from Y. lipolytica as a food ingredient, the genotoxic and subchronic toxicity potential of this compound was determined. Genotoxicity was examined using Salmonella typhimurium and Escherichia coli (Ames test), a chromosomal aberration assay in Chinese Hamster Ovary WBL cells, and the micronucleus test in CD-1 mice. All three assays showed no significant results due to β-carotene from Y. lipolytica. In a subchronic toxicity study in SD rats, β-carotene from Y. lipolytica was administered by oral gavage for 13weeks at 0, 125, 250 or 500mg/kg per day. Adverse effects were not observed following clinical, clinical pathology and gross- and histopathological evaluations of dosed rats; thus, the no-observed-adverse effect level (NOAEL) for β-carotene from Y. lipolytica was 500mg/kg, the highest dose used in the study. In conclusion, β-carotene derived from Y. lipolytica was shown in genotoxicity models and a standard rat subchronic rat study to have a safety profile similar to that of the current commercial products (synthetic and natural) with no unexpected ...Continue Reading

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Citations

Jan 19, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mélina RumelhardJames La Marta
Aug 8, 2015·Biotechnology Advances·Hu-Hu LiuHe Huang
Sep 1, 2015·Current Opinion in Biotechnology·Quinn Zhu, Ethel N Jackson
Jun 17, 2015·Applied Microbiology and Biotechnology·Peter GajdošMilan Čertík
May 8, 2015·Applied Microbiology and Biotechnology·Catherine Madzak
Jun 29, 2018·Food & Function·Torsten BohnRalph Rühl
Oct 8, 2017·Biotechnology and Bioengineering·Macarena LarroudeRodrigo Ledesma-Amaro
Dec 1, 2019·Microbial Cell Factories·Vijaydev GanesanMark Blenner
May 14, 2020·Applied Microbiology and Biotechnology·Congqiang ZhangHeng-Phon Too
Jun 9, 2018·Trends in Biotechnology·Kelly A Markham, Hal S Alper
Sep 19, 2021·Applied Microbiology and Biotechnology·Francisco A GuardiolaCarlos Angulo

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