The Safety of Drug Therapy in Children

Deutsches Ärzteblatt International
Stefan WimmerWolfgang Rascher

Abstract

1.7% of children taking medication on an outpatient basis in Germany have at least one adverse drug reaction (ADR). The corresponding figure for hospitalized children is estimated at 10% . This review is based on pertinent literature retrieved by a selective search in PubMed. According to reports submitted to the Drug Commission of the German Medical Association (Arzneimittelkommission der deutschen Ärzteschaft, AkdÄ), serious ADRs can arise, for example, after the administration of dimenhydrinate, α-adrenergic nose drops, enemas containing phosphate, ACE inhibitors, angiotensin-2-receptor antagonists (sartans), and methylphenidate. The causes of ADRs include overdoses, drug administration despite contraindications, and inadequate monitoring of long-term treatment. Errors can also be made in communication, labeling, and drug administration. The risk of ADRs is especially high in off-label use. Computerized physician order entry systems, individual packaging and labeling of single doses, and the use of bar codes for patient and drug identification can help prevent such errors. The process of drug administration should be optimized through suitable interventions and electronic support, with due consideration of local circumstance...Continue Reading

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Citations

Jun 15, 2016·Deutsches Ärzteblatt International·Jürgen Fridrich
Jun 15, 2016·Deutsches Ärzteblatt International·Wolfgang Rascher

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