The safety of intraocular ketorolac in rabbits

Investigative Ophthalmology & Visual Science
Eyal MargalitGerald R Christensen

Abstract

To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. Either 0.5% or 0.25% preservative-free ketorolac tromethamine ophthalmic solution (0.1 mL) was injected into the vitreous of the right eye of 15 rabbits. Physiologic saline solution (BSS; Alcon, Ft. Worth, TX) was injected into the left eye of each rabbit as a control. A standard electroretinogram and intraocular pressure measurements were obtained before injection, and repeated 1 day and 1, 2, 3, and 4 weeks after injection. After 4 weeks, the rabbits were euthanatized and the retinas examined by light and electron microscopy. Differences in the electroretinograms, intraocular pressure, and histopathology between the two eyes were recorded. Further, the elimination half-life of the drug in the vitreous was assessed. There were no statistically significant differences in electroretinograms, or intraocular pressure measurements obtained between the ketorolac-injected eyes and the control eyes. The half life of the drug was measured to be 2.3 hours. No histopathologic changes were observed in study eyes compared wit...Continue Reading

Citations

Oct 28, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gholam A PeymanRichard Fiscella
Apr 6, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Vasilios F DiakonisMiltiadis K Tsilimbaris
Jul 16, 2008·Retina·Izabela KomarowskaAnat Loewenstein
Oct 7, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Filiz AfrashiUmut Sahar
Jul 22, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Eyal MargalitAllen Katz
Feb 18, 2010·Survey of Ophthalmology·Stephen J KimLee M Jampol
Aug 18, 2009·Survey of Ophthalmology·Eduardo B RodriguesMichel E Farah
Feb 6, 2019·Cutaneous and Ocular Toxicology·Cezmi DoganBurak Mergen

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