The safety of mesalamine in human pregnancy: a prospective controlled cohort study

Gastroenterology
O Diav-CitrinG Koren

Abstract

Mesalamine is a first-line drug in the treatment of inflammatory bowel disease. Information regarding human pregnancy experience with mesalamine has been scarce and uncontrolled despite its frequent use in women of childbearing age. The aim of this study was to examine the fetal safety of mesalamine. The Motherisk Program prospectively enrolled and followed up 165 women exposed to mesalamine during pregnancy, 146 of whom had first trimester exposure. Pregnancy outcome was compared with that of a matched control group, who were counseled for nonteratogenic exposure. There was no increase in major malformations (1 of 127 [0.8%] for mesalamine vs. 5 of 131 [3.8%] for nonteratogenic controls; P = 0.23). There was an increase in the rate of preterm deliveries (13.0% for mesalamine vs. 4.7% for nonteratogenic controls; P = 0.02), a decrease in the mean maternal weight gain during pregnancy (13.1 +/- 6.3 kg for mesalamine vs. 15.6 +/- 6.0 kg for nonteratogenic controls; P = 0.0002), and a decrease in the mean birth weight (3253 +/- 546 g for mesalamine vs. 3461 +/- 542 g for nonteratogenic controls; P = 0.0005). There were no significant differences in the maternal obstetric history, rates of live births, miscarriages, pregnancy termi...Continue Reading

References

Apr 1, 1989·American Journal of Obstetrics and Gynecology·D M FedorkowC A Nimrod
Nov 1, 1986·British Journal of Obstetrics and Gynaecology·R J Porter, G M Stirrat
Jul 1, 1981·Diseases of the Colon and Rectum·N LevyI Teodor
Jan 1, 1981·Scandinavian Journal of Gastroenterology·G JärnerotE Esbjörner
Feb 1, 1993·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·J Stevenson, I W Anderson
Feb 1, 1996·Obstetrics and Gynecology·G R AlexanderM Kogan

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Citations

Aug 10, 1999·Teratology·M L Martínez-Frías, E Rodríguez-Pinilla
Jul 16, 2008·Inflammatory Bowel Diseases·Marla DubinskyUma Mahadevan
Aug 21, 2009·Inflammatory Bowel Diseases·Stephen B Hanauer
Aug 13, 2013·Archives of Gynecology and Obstetrics·Bram P Wispelwey, Eyal Sheiner
Nov 13, 2008·Langenbeck's Archives of Surgery·Ralf CzymekHans-Peter Bruch
Apr 14, 2010·Journal of Inherited Metabolic Disease·Aditi I DagliDavid A Weinstein
Jul 27, 2001·Current Treatment Options in Gastroenterology·Ramona Rajapakse, Burton I. Korelitz
May 15, 2003·Current Treatment Options in Gastroenterology·Richard S. Tilson, Sonia Friedman
May 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Chandrashekhar Thukral, Jacqueline L Wolf
Aug 2, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Jutta KellerPeter Layer
Dec 9, 1998·Alimentary Pharmacology & Therapeutics·J M Subhani, M I Hamiliton
Oct 7, 2006·Current Opinion in Gastroenterology·C J Ooi, B E Sands
Oct 7, 2006·Current Opinion in Gastroenterology·S B Hanauer
Feb 11, 2005·Current Opinion in Gastroenterology·Jeffry A Katz
Jun 1, 2001·Inflammatory Bowel Diseases·J A Katz, G Pore
Mar 23, 2007·Journal of Gastroenterology and Hepatology·Aurora BortoliUNKNOWN Study Group for Inflammatory Bowel Diseases GSMII
Feb 17, 2006·Gut·R CaprilliUNKNOWN European Crohn's and Colitis Organisation
Jan 18, 2002·Postgraduate Medical Journal·E M Alstead
Feb 2, 2008·Digestion·Christian MottetChristian Felley
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S Ishaq, J R Green
Mar 7, 2008·World Journal of Gastroenterology : WJG·Flavio M Habal, Nikila C Ravindran
Jun 13, 2012·World Journal of Gastroenterology : WJG·Christian P SelingerSimon Lal
Nov 14, 2013·World Journal of Gastroenterology : WJG·Zane R Gallinger, Geoffrey C Nguyen
Apr 8, 2014·World Journal of Gastroenterology : WJG·Vivian W Huang, Flavio M Habal
Jul 31, 2013·Nature Reviews. Gastroenterology & Hepatology·Ole Haagen NielsenJakob Hendel
Dec 3, 2010·Journal of Crohn's & Colitis·C Janneke van der WoudeUNKNOWN European Crohn's Colitis Organisation (ECCO)
Nov 1, 2005·Women's Health·Sunanda Kane
Dec 3, 2010·Journal of Crohn's & Colitis·R E MountifieldJ M Andrews
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jul 31, 2010·European Journal of Gastroenterology & Hepatology·Lucianna Motta CorreiaSender Jankiel Miszputen
Feb 16, 2005·Digestion·Christian MottetChristian Felley
Jan 12, 2010·Human Reproduction Update·Marleen M H J van GelderNel Roeleveld
Apr 5, 2014·Thérapie·Marleen M H J van GelderNel Roeleveld
Jan 28, 2005·Gastroentérologie Clinique Et Biologique·Bernard FlouriéEmmanuel Tiret
Aug 13, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Moamen S Refat, Soha F Mohamed
Dec 1, 2009·The Medical Clinics of North America·Uma Mahadevan
Sep 25, 2007·Best Practice & Research. Clinical Gastroenterology·Dana C Moffatt, Charles N Bernstein
Jul 31, 2007·Alimentary Pharmacology & Therapeutics·Z S HeetunC O'Morain
Oct 20, 2007·Pharmacoepidemiology and Drug Safety·Fokaline VroomLolkje T W de Jong-van den Berg

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