The safety of weekly plateletpheresis: effect on the donors' lymphocyte population

Transfusion
J A KoepkeR G Strauss

Abstract

Ten normal donors were monitored before, during, and after ten weekly donations of platelet concentrates prepared using the Haemonetics Model 30 blood processor. Analysis of these data indicates about a 20 per cent decrease of lymphocytes, with B cells being significantly decreased in half of these patients. While coincident immunoglobulin deficiencies did not develop in this short-term study, it is presumed that these would occur with a prolongation of platelet donations, as has been noted in previous studies. Additional studies are indicated to further delineate the lymphocyte depletion in normal platelet donors.

References

Jul 1, 1977·Vox Sanguinis·J NusbacherJ L MacPherson
Mar 1, 1976·Transfusion·J A KoepkeJ S Thompson
Jul 1, 1974·Transfusion·C A SchifferP H Wiernik

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Citations

Jan 1, 1991·Journal of Clinical Apheresis·C R PriorP Jacobs
Jan 1, 1994·Journal of Clinical Apheresis·R G Strauss
Jul 22, 1982·The New England Journal of Medicine·C A Schiffer, S J Slichter
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·A J Grindon
Apr 1, 1994·Transfusion Medicine Reviews·T L Simon
Jan 1, 1983·Journal of Clinical Apheresis·J P HesterE J Freireich
Jan 1, 1983·Journal of Clinical Apheresis·R G StraussJ P Hester
Jan 1, 1984·Journal of Clinical Apheresis·R G Strauss
Jan 1, 1985·Vox Sanguinis·V S BlanchetteG Rock
Nov 16, 2018·Blood·John M GansnerRichard M Kaufman
Jan 1, 1983·Vox Sanguinis·J M HealJ Nusbacher
Jan 1, 1983·Journal of Clinical Apheresis·J E MenitoveR H Aster

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