Abstract
To compare the tolerability and safety of telmisartan +/- hydrochlorothiazide (HCTZ). This retrospective analysis was performed on all hypertensive patients that were enrolled in telmisartan studies. A total of 30 double-blind (n=8023) and 20 open-label (n=8393) studies were available at the time of this analysis, and were included. Treatments investigated were placebo, telmisartan 10-160 mg, or telmisartan 10-160 mg plus HCTZ 6.25-25 mg. The incidence and causality of all adverse events (AEs) and laboratory abnormalities occurring during treatment were recorded. The incidences of all-cause AEs in the double-blind studies were: 2.73 per patient-year (PY) (36.1%; placebo); 2.03/PY (37.4%; telmisartan monotherapy) and 2.09/PY (44.8%; telmisartan plus HCTZ). The respective numbers in the open-label studies were: 0.65/PY (49.6%; telmisartan monotherapy) and 0.70/PY (40.3%; telmisartan plus HCTZ). The most frequent suspected adverse reactions were dizziness and headache, which were comparable across groups and studies. The overall incidence of drug-related laboratory abnormalities was low in all treatment groups. Treatment-related hyperuricaemia and hypokalaemia occurred in less than 0.1% of patients, respectively, treated with telm...Continue Reading
References
Dec 1, 1992·European Heart Journal·V Papademetriou
Dec 1, 1992·European Heart Journal·B N PrichardA S Woolf
Jan 1, 1989·Journal of Cardiovascular Pharmacology·M H Weinberger
Mar 1, 1988·Hypertension·M H Weinberger
Apr 1, 1996·Clinical and Experimental Hypertension : CHE·F V Costa
Jul 1, 1996·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A Overlack
Apr 1, 1997·Journal of Human Hypertension·P Marques-Vidal, J Tuomilehto
Apr 8, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W VleemingD J de Wildt
Sep 16, 1998·Clinical Therapeutics·B S Bloom
Oct 3, 2000·The Journal of International Medical Research·J StangierW Roth
Sep 18, 2001·Drugs·M SharpeK L Goa
Oct 17, 2001·Journal of Cardiovascular Pharmacology·J StangierJ H Jonkman
Dec 6, 2001·Current Hypertension Reports·M I Nunes
Jan 5, 2002·The New England Journal of Medicine·J N CohnUNKNOWN Valsartan Heart Failure Trial Investigators
Sep 21, 2002·Lancet·Kenneth DicksteinUNKNOWN OPTIMAAL Steering Committee of the OPTIMAAL Study Group
Nov 12, 2003·The New England Journal of Medicine·Marc A PfefferUNKNOWN Valsartan in Acute Myocardial Infarction Trial Investigators
Apr 6, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Martin C MichelUwe Heemann
Aug 10, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·John L Reid
Jan 10, 2006·Drugs·Anna J Battershill, Lesley J Scott
Sep 8, 2006·The Journal of Clinical Hypertension·William B WhiteJoel M Neutel
Oct 18, 2006·The Journal of Pharmacology and Experimental Therapeutics·Takashi IwanagaIkumi Tamai
Oct 4, 2007·Cardiovascular Diabetology·Arya M SharmaYves Lacourcière
Dec 1, 2007·American Journal of Hypertension·Francesca ViazziRoberto Pontremoli
Citations
Nov 20, 2009·Current Medical Research and Opinion·J M Neutel
Apr 21, 2011·Drugs·James E Frampton
Jan 10, 2012·Expert Opinion on Pharmacotherapy·Sripal Bangalore, Ludwin Ley
Oct 4, 2012·Expert Review of Cardiovascular Therapy·Massimo Volpe
May 2, 2020·Drug Development Research·Rodolfo Pedro RothlinFacundo Germán Pelorosso
Sep 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muchtaridi MuchtaridiHabibah A Wahab
Jul 2, 2011·Current Medical Research and Opinion·Luis M Ruilope
Jul 17, 2009·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Michael Weber
Feb 11, 2010·Current Medical Research and Opinion·Sverre E KjeldsenGiuseppe Mancia
Jun 5, 2013·The Journal of Clinical Hypertension·Sverre E KjeldsenRobert M Guthrie
Sep 29, 2011·Acta Diabetologica·Zemin Cao, Mark E Cooper
Feb 5, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Harold BaysHelmut Schumacher
Dec 16, 2010·Cardiovascular Research·Chi Yung YuenYu Huang
Jun 10, 2010·Southern Medical Journal·Sandeep A Saha
Nov 26, 2011·Expert Review of Clinical Pharmacology·Paolo VerdecchiaGianpaolo Reboldi
May 20, 2014·Current Medical Research and Opinion·Steen NeldamJoel M Neutel
Oct 24, 2019·Kardiologiia·A V NikitinM N Latisheva
Oct 12, 2012·Expert Opinion on Pharmacotherapy·L M Ruilope, Helmut Schumacher
Apr 14, 2015·Gastroenterology Research and Practice·S GittoP Andreone
Oct 26, 2012·Clinical and Experimental Hypertension : CHE·Henry A PunziHelmut Schumacher
Jun 12, 2013·Expert Review of Cardiovascular Therapy·Sverre KjeldsenThomas Unger
Apr 16, 2021·Frontiers in Pharmacology·Rodolfo Pedro RothlinEduardo Spitzer
Jun 22, 2012·Clinical Therapeutics·Dingliang L ZhuLuis M Ruilope
Jul 1, 2021·EClinicalMedicine·Mariano DuarteRodolfo P Rothlin