The saga of schistosome migration and attrition

R Alan Wilson


Schistosomes infect the mammalian host by direct penetration of the skin and must then undergo a protracted migration to the site of parasitization, for Schistosoma mansoni the hepatic portal vasculature. This article reviews the work published roughly between 1976 and 1986 that clarified our understanding of the process in the laboratory mouse. A combination of histopathology, larval injection experiments and autoradiographic tracking revealed that migration involved one to several circuits of the pulmonary-systemic vasculature before chance delivery in cardiac output to splanchnic arteries that lead indirectly to the portal tract. The kinetics of migration through different capillary beds was established, with the lungs of naïve mice not the skin proving the greatest obstacle; a proportion of schistosomula entered the alveoli from where they did not recover. The 'immunity' displayed by mice with a chronic infection was shown to be an artefact of a 'leaky' hepatic portal system, generated as a result of egg-induced hepatic pathology. The blockade of pulmonary migration was exacerbated in mice vaccinated with irradiated cercariae by immune-mediated inflammatory foci that developed around lung schistosomula thus decreasing the p...Continue Reading


Aug 1, 1979·Parasitology·P R Wheater, R Alan Wilson
Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Sep 1, 1978·The American Journal of Tropical Medicine and Hygiene·D A DeanK D Murrell
Dec 1, 1978·Parasitology·P Miller, R Alan Wilson
Nov 1, 1992·The Journal of Infectious Diseases·M J Laxer, C U Tuazon
Jan 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·R Alan WilsonG D Reid
Dec 1, 1989·Parasitology·Patricia S Coulson, R Alan Wilson
Apr 1, 1986·Parasitology·J E Crabtree, R Alan Wilson
Nov 1, 1986·The American Journal of Tropical Medicine and Hygiene·P M KnopfD A Dean
Jan 1, 1985·The American Journal of Tropical Medicine and Hygiene·F Von LichtenbergA Sher
Oct 6, 1969·Annals of the New York Academy of Sciences·S R Smithers, R J Terry
Jan 1, 1969·Advances in Parasitology·S R Smithers, R J Terry
Jan 1, 1968·Archives of Surgery·R E MaddenM Schwartz
Sep 1, 1967·The American Journal of Tropical Medicine and Hygiene·N E Wilks
Jul 1, 1953·Transactions of the Royal Society of Tropical Medicine and Hygiene·O D STANDEN
Apr 1, 1965·Experimental Parasitology·J A CLEGG
Aug 24, 2004·Infection and Immunity·Thomas M KariukiPatricia S Coulson


Sep 30, 2010·PLoS Neglected Tropical Diseases·Nicolas SalemJames P Basilion
Apr 22, 2011·The Journal of Parasitology·Walter A BlankRonald E Blanton
Feb 19, 2016·Parasites & Vectors·R Alan WilsonWilliam Castro-Borges
Nov 13, 2015·Expert Review of Proteomics·Patrick DriguezGeoffrey N Gobert
Jan 23, 2015·Pulmonary Circulation·Demosthenes G PapamatheakisJess Mandel
Sep 1, 2009·Trends in Parasitology·R Alan Wilson, Patricia S Coulson
May 8, 2013·Parasite Immunology·Patrick J Skelly
Aug 22, 2014·Parasite Immunology·Daniel G Colley, W Evan Secor
Apr 5, 2014·Lancet·Daniel G ColleyCharles H King
May 1, 2015·Frontiers in Genetics·Arnon D Jurberg, Paul J Brindley
Jul 31, 2014·Molecular and Biochemical Parasitology·Geoffrey N GobertDonald P McManus
Mar 31, 2018·Advanced Healthcare Materials·Pengyang LiBo Wang
Aug 1, 2015·Clinical Microbiology Reviews·Kosala G A D WeerakoonDonald P McManus
Jan 29, 2019·PLoS Neglected Tropical Diseases·Sören FrahmClarissa Prazeres da Costa
May 7, 2020·PLoS Neglected Tropical Diseases·Arporn WangwiwatsinMatthew Berriman
Jul 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wen-Jun ChengHong Jiang
Sep 21, 2018·Frontiers in Immunology·Camila Oliveira Silva SouzaLúcia Helena Faccioli
Nov 11, 2019·Parasites & Vectors·Gwendoline DeslyperCelia V Holland
Jun 6, 2020·Tropical Medicine & International Health : TM & IH·Tariro L Mduluza-JokonyaTakafira Mduluza
Sep 15, 2020·Frontiers in Microbiology·Camila Oliveira Silva SouzaLúcia Helena Faccioli
Mar 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark S WilsonThomas A Wynn
Aug 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jayhun LeePhillip A Newmark
Dec 20, 2020·Nature Communications·Carmen Lidia Diaz SoriaMatthew Berriman
Dec 22, 2017·Emerging Topics in Life Sciences·R Alan WilsonWilliam Castro-Borges
Oct 17, 2020·Scientific Reports·Tobias LindnerMartina Sombetzki
Apr 25, 2021·Trends in Parasitology·Dania Nanes SarfatiBo Wang
May 7, 2021·Frontiers in Immunology·Emma L HoulderAndrew S MacDonald
May 10, 2021·Frontiers in Immunology· AnisuzzamanClarissa Prazeres da Costa

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