The Salivary Scavenger and Agglutinin (SALSA) in Healthy and Complicated Pregnancy

PloS One
Martin Parnov ReichhardtSeppo Meri

Abstract

Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. The etiology is not clear, but an immune attack towards components of placenta or fetus has been indicated. This involves activation of the complement system in the placenta. We have previously described the presence of the complement-regulating protein salivary scavenger and agglutinin (SALSA) in amniotic fluid. In this study we investigated the potential role of SALSA in pregnancy by analyzing its presence in amniotic fluid and placental tissue during healthy and complicated pregnancies. SALSA levels in amniotic fluid increased during pregnancy. Before 20 weeks of gestation the levels were slightly higher in patients who later developed pre-eclampsia than in gestation age-matched controls. In the placenta of pre-eclamptic patients syncytial damage is often followed by the formation of fibrinoid structures. SALSA was found clustered into these fibrinoid structures in partial co-localization with complement C1q and fibronectin. In vitro analysis showed direct protein binding of SALSA to fibronectin. SALSA binds also to fibrin/fibrinogen but did not interfere with the blood clotting process in vitro. Thus, in addition to antimicrobial d...Continue Reading

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Citations

Mar 13, 2019·Molecular Oral Microbiology·Takahiko Oho, Emi Nagata
Oct 18, 2019·Frontiers in Immunology·Martin P ReichhardtTimo Tuuri
Jun 15, 2017·Frontiers in Immunology·A Inkeri LokkiSeppo Meri
Jul 3, 2017·Molecular Immunology·M P ReichhardtS Meri

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Methods Mentioned

BETA
bronchoalveolar
fluorescence microscopy
ELISA

Software Mentioned

Olympus DP Controller
SALSA
Olympus DP Manager
VIS Visiopharm Integrator System

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