The same but different: the biology of Theileria sporozoite entry into bovine cells
Theileria are important tick-transmitted protozoan parasites that infect wild Bovidae and domestic animals throughout much of the world. Much of our understanding of Theileria sporozoite invasion of bovine cells is based on work on T. parva, the causative agent of East Coast fever in cattle throughout east, central and southern Africa. Sporozoite entry involves a defined series of sequential but separable steps that differ in important details from the invasion process in other apicomplexans such as Plasmodium and Toxoplasma. While the morphological features of invasion are fairly well documented, the detailed biology of the individual steps is only now becoming clear. This review summarizes much of this recent work on the biology of sporozoite entry. In particular, recent studies on the role of Ca2+ and cell activation processes in sporozoite entry suggest that the initial sporozoite binding event triggers the mobilization of intrasporozoite Ca2+ and the activation of both kinase and G-protein associated signalling processes in the parasite. These processes in turn regulate the invasive capacity of the sporozoite although the identity of these parasite molecules and how they contribute to the invasion process remain to be dete...Continue Reading
Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation
Localization of a Toxoplasma gondii rhoptry protein by immunoelectron microscopy during and after host cell penetration
Binding of malarial circumsporozoite protein to sulfatides [Gal(3-SO4)beta 1-Cer] and cholesterol-3-sulfate and its dependence on disulfide bond formation between cysteines in region II
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins
Malaria sporozoites release circumsporozoite protein from their apical end and translocate it along their surface
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
The entry of Theileria parva sporozoites into bovine lymphocytes: evidence for MHC class I involvement
Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva
Role of calcium and erythrocyte cytoskeleton phosphorylation in the invasion of Plasmodium falciparum
Theileria annulata sporozoite surface antigen expressed in Escherichia coli elicits neutralizing antibody
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Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
Invasion and intracellular development of Theileria annulata sporozoites in lymphoblastoid cell lines already transformed by T. annulata (Hissar), T. annulata (Ankara) and T. parva (Muguga)
Theileria parva (Muguga) infects bovine T-lymphocytes in vivo and induces coexpression of BoT4 and BoT8
Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design
Letter: Infection and transformation of bovine lymphoid cells in vitro by infective particles of Theileria parva
Fine structure and invasive behaviour of the early developmental stages of Theileria annulata in vitro
The early events of infection with Theileria parva in cattle: infectivity for cattle of leukocytes incubated in vitro with sporozoites
Factors affecting the capacity of Theileria annulata sporozoites to invade bovine peripheral blood lymphocytes
Interaction of sporozoites of Theileria parva with bovine lymphocytes in vitro. I. Early events after invasion
Factors affecting the ability of isolated Plasmodium knowlesi merozoites to attach to and invade erythrocytes
Theileria annulata sporozoite surface antigen (SPAG-1) contains neutralizing determinants in the C terminus
Analysis of the high molecular weight rhoptry complex of Plasmodium falciparum using monoclonal antibodies
Salmonella typhimurium invasion of epithelial cells: role of induced host cell tyrosine protein phosphorylation.
Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen
A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line.
Lymphocytes and macrophages are infected by Theileria equi, but T cells and B cells are not required to establish infection in vivo
Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton
Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes
Theileria parva: sporozoite entry into bovine lymphocytes is not dependent on the parasite cytoskeleton
Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes
Theileriosis in a Missouri beef herd caused by Theileria buffeli: case report, herd investigation, ultrastructure, phylogenetic analysis, and experimental transmission
Theileria: intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
Factors associated with seroconversion to the major piroplasm surface protein of the bovine haemoparasite Theileria orientalis
Clinical and Pathological Studies on Cattle Experimentally Infected with Theileria annulata in China
Theileria equi claudin like apicomplexan microneme protein contains neutralization-sensitive epitopes and interacts with components of the equine erythrocyte membrane skeleton.
Theileria's Strategies and Effector Mechanisms for Host Cell Transformation: From Invasion to Immortalization.
Calcium & Bioenergetics
Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.