The sample size required for intervention studies on fracture prevention can be decreased by using a bone resorption marker in the inclusion criteria: prospective study of a subset of the Nagano Cohort, on behalf of the Adequate Treatment of Osteoporosis (A-TOP) Research Group.

Journal of Bone and Mineral Metabolism
M ShirakiAdequate Treatment of Osteoporosis (A-TOP) Research Group

Abstract

In drug developments for osteoporosis, large-scale and longterm fracture prevention studies have been required. We investigated whether or not it was possible to reduce the sample size and observation period under new selection criteria for an osteoporotic fracture-prevention study. A Poisson regression model was used to identify independent risks for incident vertebral fracture in 515 postmenopausal women who had had no intervention for osteoporosis; this group was a subset of Nagano Cohort participants. The total observation period for this group was 2,577 person-years, and a total of 146 new vertebral fractures were observed. Risk assessment for incident vertebral fracture among numerical covariates revealed that the following items showed significant independent risks for incident fractures; namely, baseline age (hazard ratio [HR]; 1.84; 95% confidence interval (CI), 1.44-2.35; P < 0.001), number of preexisting vertebral fractures (HR, 1.28; 95% CI, 1.17-1.40; P < 0.001), baseline lumbar bone mineral density (LBMD) (HR, 0.79; 95% CI, 0.71-0.88; P < 0.001), and urinary excretion of deoxypyridinoline (DPD) (HR, 1.18; 95% CI, 1.03-1.35; P = 0.016). Because the initial urinary excretion of DPD was found to be a risk for inciden...Continue Reading

References

Jan 1, 1992·Bone·J A Kanis, E V McCloskey
May 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P D RossR D Wasnich
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K GenantS R Cummings
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Sep 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M ShirakiY Ouchi
Aug 18, 1997·The American Journal of Medicine·P Lips
Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M KlotzbuecherM Berger
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A OleksikJ Kanis
Aug 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Oct 31, 2001·Journal of Bone and Mineral Metabolism·H OrimoH Kishimoto
Nov 17, 2001·Arthritis and Rheumatism·S L SilvermanUNKNOWN Health-Related Quality of Life Subgroup of the Multiple Outcomes of Raloxifene Evaluation Study
Feb 11, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D K RoyUNKNOWN European Prospective Osteoporosis Study (EPOS)
Aug 22, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Saeko FujiwaraMasao Fukunaga
Jan 30, 2004·The New England Journal of Medicine·Pierre J MeunierJean-Yves Reginster
Mar 5, 2004·Journal of Bone and Mineral Metabolism·Masao FukunagaHajime Orimo
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth Barrett-ConnorLouis M Sherwood
Mar 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pierre D DelmasUNKNOWN IMPACT Study Group

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Citations

Feb 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M ShirakiS Tanaka
Jul 23, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Task Force of the FRAX Initiative
Dec 21, 2007·Journal of Bone and Mineral Metabolism·Masataka ShirakiToshitaka Nakamura
Dec 21, 2007·Journal of Bone and Mineral Metabolism·Naoko TsugawaToshio Okano
Mar 12, 2010·Journal of Bone and Mineral Metabolism·Masataka ShirakiToshio Okano
Apr 29, 2010·Journal of Bone and Mineral Metabolism·Hirose YamauchiHajime Orimo
Jun 30, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shota IkegamiHiroyuki Kato
Oct 24, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M S LeeE Ernst
Oct 20, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCE
Oct 4, 2019·The Cochrane Database of Systematic Reviews·Li YeChunjie Li
Dec 9, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R WatanabeD Inoue
Jun 19, 2007·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Takayuki Hosoi

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