The saponin of red ginseng protects the cardiac myocytes against ischemic injury in vitro and in vivo

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Hai-Xia LiPeng-Fei Tu

Abstract

Steamed root of Panax ginseng C.A. Mayer, known as "red ginseng", differs from other ginseng preparations in terms of its saponin components and content, as some partly deglycosylated saponins are produced as artifacts during the steaming process. However, whether saponins derived from red ginseng (SRG) can have a protective effect on cardiomyocytes remains unknown. The present study aimed to explore the effect of SRG on myocardial ischemia in vitro and in vivo. MTT assays revealed that SRG pretreatment significantly increased the viability of cardiomyocytes injured by Na(2)S(2)O(4) hypoxia in vitro. This effect was almost completely abolished by glibenclamide, a blocker of the ATP-sensitive potassium channel, but the cardioprotective activity of SRG was not influenced by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002. SRG also significantly reduced the Na(2)S(2)O(4)-induced increase in intracellular calcium, as shown by Fluo-3/AM probes with flow cytometry. Adult rat heart ischemia, which was induced by ligation of the left anterior descending coronary artery, was employed for the in vivo analysis. SRG pretreatment reduced infarct size and resulted in a higher left ventricle (LV) developed pressure, LV (+)dP/dt(ma...Continue Reading

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Citations

Oct 15, 2013·Acta Pharmacologica Sinica·Dong-soon Im, Seung-yeol Nah
Apr 5, 2013·Journal of Food Science·Chu ChuLi Liu
Apr 20, 2014·BioMed Research International·Cheng-Chia TsaiJia-Wei Lin
Apr 2, 2014·BioMed Research International·Jia-Wei LinChiang-Shan Niu
Jun 19, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ioanna AndreadouEfstathios K Iliodromitis
Oct 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·S Y YeonD Chang
May 25, 2021·Journal of Ginseng Research·Young-Jin JangJong-Hoon Kim

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