The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies

Anastassios C Papageorgiou, Imran Mohsin


Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of the Coronavirus disease (COVID-19) pandemic, has so far resulted in more than 1.1 M deaths and 40 M cases worldwide with no confirmed remedy yet available. Since the first outbreak in Wuhan, China in December 2019, researchers across the globe have been in a race to develop therapies and vaccines against the disease. SARS-CoV-2, similar to other previously identified Coronaviridae family members, encodes several structural proteins, such as spike, envelope, membrane, and nucleocapsid, that are responsible for host penetration, binding, recycling, and pathogenesis. Structural biology has been a key player in understanding the viral infection mechanism and in developing intervention strategies against the new coronavirus. The spike glycoprotein has drawn considerable attention as a means to block viral entry owing to its interactions with the human angiotensin-converting enzyme 2 (ACE2), which acts as a receptor. Here, we review the current knowledge of SARS-CoV-2 and its interactions with ACE2 and antibodies. Structural information of SARS-CoV-2 spike glycoprotein and its complexes with ACE2 and antibodies can provide key input for the developme...Continue Reading


Nov 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kailang WuFang Li
Feb 11, 2015·Antiviral Research·Yanchen ZhouGraham Simmons
Aug 28, 2015·Journal of Virology·Edgar DavidsonBenjamin J Doranz
Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen
Oct 30, 2016·Current Opinion in Structural Biology·Rahul RamanRam Sasisekharan
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Jan 4, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andrea Marzi, Chad E Mire
Jun 5, 2019·Nature Structural & Molecular Biology·M Alejandra TortoriciDavid Veesler
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 13, 2020·Cellular & Molecular Immunology·Shuai XiaLu Lu
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Mar 21, 2020·Current Biology : CB·Tao ZhangZhigang Zhang
Mar 21, 2020·Lancet·Juliet BedfordUNKNOWN WHO Strategic and Technical Advisory Group for Infectious Hazards
Mar 30, 2020·Cell·Yong-Zhen Zhang, Edward C Holmes
Apr 7, 2020·Trends in Immunology·Shibo JiangLanying Du
Apr 22, 2020·Journal of Medical Virology·Sunitha M KasibhatlaUrmila Kulkarni-Kale
May 4, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dwight L McKeeCord Naujokat
May 6, 2020·Science·Yasunori WatanabeMax Crispin
May 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jian ShangFang Li
May 12, 2020·Frontiers in Microbiology·Longping V TseRalph S Baric
May 22, 2020·Life Sciences·Venkatesh PooladandaChandraiah Godugu
May 23, 2020·PLoS Pathogens·Daolin TangRui Kang
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Dora PintoDavide Corti

❮ Previous
Next ❯


Feb 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel
Apr 6, 2021·Computational and Structural Biotechnology Journal·Amie Jobe, Ranjit Vijayan
May 25, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li Jun YangVincent Kam Wai Wong
Aug 17, 2021·Frontiers in Public Health·Emmanuelle LogetteHenry Markram

❮ Previous
Next ❯

Methods Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.