The Scale of Functional Specialization within Human Prefrontal Cortex.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sam J GilbertJon S Simons

Abstract

At what scale is it possible to observe consistent functional specialization within human prefrontal cortex (PFC), reproducible from one individual to the next? Some studies suggest gross functional divisions between large regions of PFC, but it is not known whether PFC exhibits specialization at the fine-grained scale known to differentiate posterior cortical functions. We used fMRI to confirm a three-way segregation of function between three regions of medial anterior PFC, each centered on coordinates within 15 mm of the other two. Naive participants performed three tasks based on earlier studies, and we investigated activity at regions defined by previous results. In each task, signal was significantly greater at the predicted region than the other two, just millimeters away. These results indicate reproducible functional specialization within PFC, at a much finer scale than previously demonstrated. Furthermore, these findings suggest that divergent results from previous studies may reflect the recruitment of functionally distinct regions and that "reverse inference" should be undertaken with caution.

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Citations

Oct 7, 2011·Cerebral Cortex·Roland G BenoitPaul W Burgess
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie BudaJon S Simons
Aug 7, 2013·Cognitive, Affective & Behavioral Neuroscience·Valerie C BrandtJon S Simons
Feb 24, 2016·Journal of Autism and Developmental Disorders·Rose A CooperJon S Simons
Nov 3, 2010·Neuroscience and Biobehavioral Reviews·Stephanie BurnettSarah-Jayne Blakemore
Oct 22, 2014·Cerebral Cortex·Simon B EickhoffLukas Hensel
Sep 25, 2014·Cerebral Cortex·B T Thomas YeoMichael W L Chee
Jun 15, 2014·Brain Structure & Function·Massieh MoayediKaren D Davis
Feb 24, 2015·Brain Connectivity·Marisa LoitfelderSerge A Rombouts
Jan 5, 2011·NeuroImage·AnnaLaura LagioiaMartin Debbané
Apr 9, 2015·Frontiers in Human Neuroscience·Hugo J Spiers, Sam J Gilbert
Sep 25, 2010·Trends in Neurosciences·Charles R E WilsonMark G Baxter
Jun 21, 2016·The European Journal of Neuroscience·Fabien AlcarazMathieu Wolff
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Jan 23, 2020·The American Journal of Psychiatry·Lisa M McTeagueAmit Etkin
Apr 30, 2017·Frontiers in Neuroscience·Xu Lei, Keren Liao

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