The scallop IGF2 mRNA-binding protein gene PyIMP and association of a synonymous mutation with growth traits

Genes & Genetic Systems
Xianhui NingZhenmin Bao

Abstract

Insulin-like growth factor 2 mRNA-binding proteins (IMPs) function in localization, stability and translational control of their target RNAs. In this study, we identified an IMP gene (PyIMP) from Yesso scallop, Patinopecten yessoensis. The complete DNA sequence of PyIMP was 22,875 bp, consisting of seventeen exons and sixteen introns. The full-length cDNA sequence was 3,293 bp, with an open reading frame of 1,776 bp, encoding 592 amino acids. PyIMP exhibited characters typical of IMPs, namely two RNA recognition motifs and four hnRNP K homology domains. Real-time quantitative reverse transcription PCR analysis indicated that PyIMP was universally expressed, with higher expression levels in the gonad of adult scallops, and in gastrulae and trochophore larvae at developmental stages. A synonymous mutation SNP, c.852A>G, which showed significant associations with growth traits of Yesso scallop, was identified in this gene. Scallops with the AA genotype at this locus had significantly higher trait values than those with the GG genotype for shell length, shell height, body weight, soft tissue weight and striated muscle weight (P < 0.05). Meanwhile, the expression of PyIMP in AA type scallops was significantly higher than that in the...Continue Reading

References

Mar 1, 1981·Cell·P A Sharp
Apr 1, 1997·Molecular and Cellular Biology·A F RossR H Singer
May 20, 1998·Current Biology : CB·J O DeshlerB J Schnapp
Dec 16, 1998·Science·UNKNOWN C. elegans Sequencing Consortium
Mar 25, 2000·Science·M D AdamsJ C Venter
Sep 21, 2000·Journal of the National Cancer Institute·H Yu, T Rohan
Apr 9, 2002·Current Biology : CB·Sunjong KwonBruce J Schnapp
May 4, 2004·Molecular and Cellular Biology·Thomas V O HansenFinn C Nielsen
Dec 17, 2004·Biology of the Cell·Joel K Yisraeli
Aug 16, 2005·Trends in Genetics : TIG·Georgia Panopoulou, Albert J Poustka
Mar 17, 2006·The EMBO Journal·Jonas VikesaaFinn C Nielsen
Nov 15, 2006·The Journal of Cell Biology·Nadine StöhrStefan Hüttelmaier
May 12, 2009·Journal of Molecular Endocrinology·Jan ChristiansenFinn C Nielsen
Apr 9, 2010·Nature Reviews. Genetics·Hadas KerenGil Ast
Sep 6, 2011·Nature·Kevin M KocotKenneth M Halanych
Oct 17, 2012·Cellular and Molecular Life Sciences : CMLS·Jessica L BellStefan Hüttelmaier
Mar 1, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Linda Z Holland, Takayuki Onai

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