The Schultz-Dale reaction of the guinea-pig ileum: influence by beta-adrenoceptor agonists and theophylline

Agents and Actions
G M Laekeman, A G Herman


One of the organs that can be used to study the Schultz-Dale reaction, is the guinea-pig ileum. The reaction is characterized by a specific pattern: a quick contraction, followed by a quick relaxation and a second, more slow contraction. A description is given of this typical reaction. Selective inhibition of the slow contraction could be obtained using beta-adrenoceptor agonists. Also theophylline inhibited the slow contraction, but this inhibition was only selective within a narrow range of concentration. These findings encourage further investigation about a possible involvement of cyclic nucleotides in the liberation of the mediators involved in the Schultz-Dale reaction of the guinea-pig ileum. Furthermore they provide more information about this preparation which could be used as a screening model for anti-allergic drugs of distinct pharmacological groups.


Jul 1, 1979·British Journal of Pharmacology·A G HermanH A van Beek
May 1, 1978·Prostaglandins·G M Laekeman, A G Herman
Jul 1, 1970·British Journal of Pharmacology·M M Dale, L Zilletti
Jan 1, 1971·International Archives of Allergy and Applied Immunology·R P Orange, K F Austen
Apr 1, 1968·Archives internationales de physiologie et de biochimie·M Cîrstea, G Suhaciu
Dec 30, 1971·Annals of the New York Academy of Sciences·L TrinerS H Ngai
Dec 1, 1952·The Journal of Physiology·J L MONGAR, H O Schild
Jul 1, 1959·The American Journal of Physiology·M DWORETZKY
Apr 25, 1960·Acta Physiologica Scandinavica·L O BOREUS, N CHAKRAVARTY

Related Concepts

Contraction (Finding)
Adrenergic beta-Agonists
Terbutalin von ct
Adrenergic Receptor
Entire Ileum

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