The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.

Science
J M McCuneI L Weissman

Abstract

The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.

References

Jul 1, 1975·The Journal of Experimental Medicine·N M Le Douarin, F V Jotereau
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Apr 13, 1978·Nature·C G Fathman, H Hengartner
Dec 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R V RouseB A Kyewski
Jul 1, 1988·Science·G J SpangrudeI L Weissman
Jan 1, 1988·Immunology Today·M Sykes, D H Sachs
Mar 1, 1988·The Journal of Experimental Medicine·G C BosmaM J Bosma
Mar 1, 1988·Reviews of Infectious Diseases·I Weissman
Jun 25, 1987·The New England Journal of Medicine·W T HughesL Lott
Sep 5, 1981·Journal of Molecular Biology·P L DeiningerC W Schmid
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·W T Hughes, B L Smith
Feb 10, 1983·Nature·G C BosmaM J Bosma
Aug 1, 1982·Human Immunology·R V RouseI L Weissman
Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR
Mar 10, 1956·Nature·C E FORDJ F LOUTIT
May 1, 1983·Immunology Today·D R ParksL A Herzenberg

❮ Previous
Next ❯

Citations

Mar 1, 1996·Reviews in Medical Virology·J T Safrit, R A Koup
Jul 1, 1991·The American Journal of Anatomy·L D Shultz
Dec 14, 2004·European Journal of Immunology·José A M BorghansFrank Miedema
Jan 1, 1993·Journal of Clinical Laboratory Analysis·R I FoxH I Kang
Oct 1, 1991·Cancer Metastasis Reviews·B M Mueller, R A Reisfeld
Sep 1, 1992·Journal of Clinical Immunology·T S Barry, B F Haynes
Apr 1, 1995·Journal of Biomedical Science·F.Y.T. TungJ.B. Hendricks
Mar 1, 1997·Journal of Biomedical Science·S. KaushalJ.D. Mosca
Feb 28, 1998·Immunologic Research·G N Gaulton
Jan 1, 1990·Immunologic Research·S KomoriM I Greene
Sep 7, 2002·International Journal of Hematology·Jun-ichi MiyagiYuetsu Tanaka
Jan 10, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Santhi GorantlaLarisa Y Poluektova
Jan 20, 2009·Current HIV/AIDS Reports·Paul W Denton, J Victor Garcia
Aug 30, 2008·Immunologic Research·Derek HolmesLishan Su
Nov 22, 2013·International Journal of Hematology·Fumihiko Ishikawa
Mar 21, 1991·Journal of Immunological Methods·S Froidevaux, F Loor
Oct 12, 1995·Journal of Immunological Methods·K YoshinariY Yamaguchi
Jan 1, 1990·Life Sciences·N EndeN M Ponzio
May 1, 1989·Veterinary Immunology and Immunopathology·H M McClureA Brodie
Feb 1, 1991·Veterinary Immunology and Immunopathology·G FritschS J Black

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.