The science of being a study participant: FEM-PrEP participants' explanations for overreporting adherence to the study pills and for the whereabouts of unused pills

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Amy L CorneliLut Van Damme

Abstract

FEM-PrEP was unable to determine whether once-daily, oral emtricitabine/tenofovir disoproxil fumarate reduces the risk of HIV acquisition among women because of low adherence. Self-reported adherence was high, and pill-count data suggested good adherence. Yet, drug concentrations revealed limited pill use. We conducted a follow-up study with former participants in Bondo, Kenya, and Pretoria, South Africa, to understand factors that had influenced overreporting of adherence and to learn the whereabouts of unused pills. Qualitative, semistructured interviews were conducted with 88 participants, and quantitative, audio computer-assisted self-interviews were conducted with 224 participants. We used thematic analysis and descriptive statistics to analyze the qualitative and quantitative data, respectively. In audio computer-assisted self-interviews, 31% (n = 70) said they had overreported adherence; the main reason was the belief that nonadherence would result in trial termination (69%, n = 48). A considerable percentage (35%, n = 78) acknowledged discarding unused pills. Few acknowledged giving their pills to someone else (4%, n = 10), and even fewer acknowledged giving them to someone with HIV (2%, n = 5). Many participants in the...Continue Reading

Associated Clinical Trials

References

Aug 1, 1960·Journal of Consulting Psychology·D P CROWNE, D MARLOWE
Jan 9, 2004·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Cynthia Waszak GearyTiburce Nyama
Jun 19, 2004·BMJ : British Medical Journal·Leah Belsky, Henry S Richardson
Nov 9, 2005·The Journal of Family Planning and Reproductive Health Care·Greg GuestLawrence Adeokun
May 23, 2008·PLoS Medicine·UNKNOWN Participants in 2006 Georgetown University Workshop on Ancillary-Care Obligations of Medical Researchers Working in Developi
Apr 24, 2009·Journal of Empirical Research on Human Research Ethics : JERHRE·Kathleen M MacqueenNatasha Mack
Dec 6, 2011·BMC Medical Research Methodology·Alexander VuSaifuddin Ahmed
Mar 13, 2012·AIDS and Behavior·Ann Bartley WilliamsJulie A Womack
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Jul 13, 2012·The New England Journal of Medicine·Lut Van DammeUNKNOWN FEM-PrEP Study Group
May 3, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Deborah DonnellConnie Celum
Aug 27, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Amy L CorneliUNKNOWN FEM-PrEP Study Group
Sep 1, 2006·African Journal of AIDS Research : AJAR·Kata ChillagDawn K Smith

❮ Previous
Next ❯

Citations

Mar 16, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kerry A ThomsonUNKNOWN Partners PrEP Study Team
Mar 10, 2016·Journal of Empirical Research on Human Research Ethics : JERHRE·Celia B FisherBrian Mustanski
Mar 20, 2016·AIDS and Behavior·K Rivet AmicoUNKNOWN iPrEx Study Team
Mar 15, 2019·Journal of the International AIDS Society·K Rivet AmicoUNKNOWN HPTN 069/A5305 Study Team and HPTN Women at Risk Committee
Mar 14, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Monica GandhiMaria L Ekstrand
Jul 23, 2019·Journal of the International AIDS Society·Connie L CelumLinda-Gail Bekker
Sep 30, 2015·Current Opinion in HIV and AIDS·Kerry A ThomsonRenee Heffron
Jul 23, 2015·Journal of the International AIDS Society·Connie L CelumJared M Baeten
Jul 23, 2015·Journal of the International AIDS Society·Carlos F CáceresKevin R O'Reilly
Feb 7, 2016·Journal of the International AIDS Society·Ariane van der StratenUNKNOWN MTN-003 VOICE Protocol Team for Microbicide Trials Network
Nov 5, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Amy CorneliLut Van Damme
Aug 10, 2016·AIDS and Behavior·Julie H Levison, Margarita Alegría
Dec 14, 2018·AIDS and Behavior·Stefanie J VaccherUNKNOWN NSW HIV Prevention Partnership Project
May 20, 2020·Current HIV/AIDS Reports·Matthew A SpinelliMonica Gandhi
Jan 23, 2017·AIDS and Behavior·Petina MusaraUNKNOWN Microbicide Trials Network-003D Study Team
Nov 7, 2015·AIDS·Ariane van der StratenUNKNOWN Microbicide Trials Network-003D Study Team

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.