The Score Model Containing Chinese Medicine Syndrome Element of Blood Stasis Presented a Better Performance Compared to APRI and FIB-4 in Diagnosing Advanced Fibrosis in Patients with Chronic Hepatitis B

Evidence-based Complementary and Alternative Medicine : ECAM
Xiao-Ling ChiGao-Shu Cai

Abstract

This study aims to explore a useful noninvasive assessment containing TCM syndrome elements for liver fibrosis in CHB patients. The demographic, clinical, and pathological data were retrospectively collected from 709 CHB patients who had ALT less than 2 times the upper limit of normal from April 2009 to October 2012. Logistical regression and area under receiver-operator curve (AUROC) were used to determine the diagnostic performances of simple tests for advanced fibrosis (Scheuer stage, F ≥ 3). Results showed that the most common TCM syndrome element observed in this CHB population was dampness and Qi stagnation, followed by blood stasis, by heat, and less by Qi deficiency and Yin deficiency. The logistical regression analysis identified AST ≥ 35 IU/L, PLT ≤ 161 × 10(9)/L, and TCM syndrome element of blood stasis as the independent risk factors for advanced fibrosis. Therefore, a score model containing these three factors was established and tested. The score model containing blood stasis resulted in a higher AUC (AUC = 0.936) compared with APRI (AUC = 0.731) and FIB-4 (AUC = 0.709). The study suggested that the score model containing TCM syndrome element of blood stasis could be used as a useful diagnostic tool for advanced f...Continue Reading

References

Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Min-De ZengXia-Qiu Zhou
Jun 8, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Shahinul AlamMobin Khan
Sep 26, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yan WangLun-Gen Lu
Mar 13, 2014·Chinese Journal of Integrative Medicine·He-ping XieYang-mei Li
Sep 27, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wissam Beaino, Carolyn J Anderson

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
FibroTest

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