The Screening Compound Collection: A Key Asset for Drug Discovery

Chimia
Christoph BossRomain Siegrist

Abstract

In this case study on an essential instrument of modern drug discovery, we summarize our successful efforts in the last four years toward enhancing the Actelion screening compound collection. A key organizational step was the establishment of the Compound Library Committee (CLC) in September 2013. This cross-functional team consisting of computational scientists, medicinal chemists and a biologist was endowed with a significant annual budget for regular new compound purchases. Based on an initial library analysis performed in 2013, the CLC developed a New Library Strategy. The established continuous library turn-over mode, and the screening library size of 300'000 compounds were maintained, while the structural library quality was increased. This was achieved by shifting the selection criteria from 'druglike' to 'leadlike' structures, enriching for non-flat structures, aiming for compound novelty, and increasing the ratio of higher cost 'Premium Compounds'. Novel chemical space was gained by adding natural compounds, macrocycles, designed and focused libraries to the collection, and through mutual exchanges of proprietary compounds with agrochemical companies. A comparative analysis in 2016 provided evidence for the positive im...Continue Reading

Citations

Dec 24, 2019·Angewandte Chemie·Line NaesborgThorsten Bach
Apr 23, 2020·Frontiers in Pharmacology·Emmanuelle LautiéJean A Boutin
Jan 17, 2021·Drug Discovery Today·Gisele NishiguchiAnang A Shelat
Nov 4, 2020·Journal of Medicinal Chemistry·Ansgar SchuffenhauerDaniel K Baeschlin

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