PMID: 15247501Jul 13, 2004Paper

The sculpturing role of fibroblast-like cells in morphogenesis

Perspectives in Biology and Medicine
F Doljanski

Abstract

Cells of multicellular organisms are semi-fluid creatures. Even when they form specific cell-cell adhesions, they cannot create a defined shape or a tissue-specific architecture. Cartilaginous organs, such as ears and noses, exemplify the fact that form is imprinted in the extracellular matrix (ECM), which leads to the conclusion that cells must have the ability to shape the ECM in which they reside. This seems to be true for most tissues. The role of the ECM as an integrator of cells into functional assemblies with defined architecture is unique to multicellular organisms. The evolution of multicellularity became possible as a consequence of cells acquiring two new properties: first, cell surface macromolecular complexes that function in cell-cell binding; and, second, an ECM that integrates cells into three-dimensional structures. These two new properties allowed the evolution of the two basic types of cells-epithelial and mesenchymal. The appearance of the latter, a fibroblast-like cell with abundant filopodia, enabled the sculpturing of the ECM and the formation of complex tissue-specific architectures.

Citations

Aug 19, 2005·Molecular Biology of the Cell·Hongmei Jiang, Frederick Grinnell
Sep 26, 2008·Pakistan Journal of Biological Sciences : PJBS·Mostafa Rezaei-TaviraniPourkhoshbakht Yousof
Sep 29, 2007·Biomechanics and Modeling in Mechanobiology·Xiaohai WanSharon R Lubkin
Feb 4, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hui ChenYing-Guang Cao
Jan 26, 2016·Seminars in Cell & Developmental Biology·Lidia Ibba-ManneschiMirko Manetti
Jan 22, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexis DesmoulièreGiulio Gabbiani
Jun 7, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elizabeth D Hay
Oct 28, 2010·Journal of Cellular and Molecular Medicine·Daniele BaniMaria-Simonetta Faussone-Pellegrini
Jan 29, 2014·Journal of Cellular and Molecular Medicine·Mirko ManettiLidia Ibba-Manneschi
Feb 19, 2014·Journal of Cellular and Molecular Medicine·Daniele Bani, Silvia Nistri
Jul 27, 2010·Biophysical Journal·Mark D StevensonKeith J Gooch
Sep 7, 2013·Marine Environmental Research·Michela SugniMaria Daniela Candia Carnevali
Nov 1, 2005·Experimental Cell Research·Frederick GrinnellHongmei Jiang
Sep 17, 2016·Trends in Cell Biology·Abraham Q Kohrman, David Q Matus
Jun 14, 2014·Nature Communications·David Q MatusDavid R Sherwood
Oct 11, 2017·Reproductive Sciences·Lutz KonradHans-Rudolf Tinneberg
Apr 19, 2017·Arkhiv patologii·Yu V LiskovaS P Salikova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Biological Reviews of the Cambridge Philosophical Society
L Ettinger, F Doljanski
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Edie C GoldsmithThomas K Borg
American Journal of Physiology. Cell Physiology
Helene M LangevinAlan K Howe
© 2022 Meta ULC. All rights reserved