The search for a potentially prebiotic synthesis of nucleotides via arabinose-3-phosphate and its cyanamide derivative

Chemistry : a European Journal
Carole AnastasiJohn D Sutherland

Abstract

For the RNA world hypothesis to be accepted, the constitutional self-assembly of RNA will have to be demonstrated. Conceptually, the simplest route to RNA involves nucleotide polymerisation. Activated pyrimidine nucleotides can be derived from arabinose-3-phosphate under potentially prebiotic conditions, but the prebiotic synthesis of this sugar phosphate has not hitherto been investigated. The results of synthetic approaches involving phosphorylation, phosphate migration and 2,3-C--C bond construction are described herein.

References

Jun 10, 2003·Chembiochem : a European Journal of Chemical Biology·Abdul-Aziz IngarJohn D Sutherland
Sep 21, 2005·Chembiochem : a European Journal of Chemical Biology·James M Smith, John D Sutherland
Dec 29, 2006·Chemistry & Biodiversity·Vinciane BorsenbergerJohn D Sutherland
Jun 6, 2007·Chembiochem : a European Journal of Chemical Biology·Matthew W PownerJohn D Sutherland

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Citations

Feb 5, 2013·The Journal of Organic Chemistry·Matthew B KraftLaura L Kiessling
May 11, 2010·Cold Spring Harbor Perspectives in Biology·John D Sutherland
Jan 24, 2018·Nature Chemistry·Clémentine GibardRamanarayanan Krishnamurthy
Apr 29, 2014·Molecular Systems Biology·Markus A KellerMarkus Ralser
Sep 21, 2019·Scientific Reports·A D CastañedaT M Orlando
Jan 13, 2011·Chemistry : a European Journal·Judit E SponerMiguel Fuentes-Cabrera
May 14, 2020·The Journal of Physical Chemistry. a·Sourav GhoshalPranab Sarkar
Nov 4, 2010·Journal of the American Chemical Society·Matthew W PownerJack W Szostak
Jul 22, 2021·Chembiochem : a European Journal of Chemical Biology·Abdulakeem Osumah, Ramanarayanan Krishnamurthy
Oct 2, 2019·ACS Central Science·Tamal DasKumar Vanka
Nov 1, 2013·Chemical Reviews·Kepa Ruiz-MirazoAndrés de la Escosura

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