The search for heterogeneity in insulin-dependent diabetes mellitus: evidence for familial and nonfamilial forms

American Journal of Medical Genetics
D A Greenberg, C E Anderson

Abstract

Using five different published sets of data, we looked at the distribution of HLA-DR genotypes among diabetic probands. It was possible to reject dominant inheritance at the HLA-associated locus, but some of the data were compatible with recessive inheritance while some were not. An attempt to reconcile the conflicting data by proposing a three-allele model apparently failed. It proved possible to resolve some of the conflicting data by proposing that simplex families represent primarily a recessive form of insulin dependent diabetes mellitus (IDDM) while multiplex families represent primarily two other subforms: one showing three-allele inheritance and one not. We also propose that the HLA locus involved in IDDM mediates the effect of an environmental agent on a second disease locus.

References

Jun 1, 1979·Diabetes·N R FaridD A Hillman
Mar 1, 1979·Diabetes Care·M ChristyA Svejgaard
Jul 1, 1978·Annals of Human Genetics·B Degnbol, A Green
May 1, 1980·Annals of Human Genetics·S E HodgeK L Lange
Jan 1, 1981·American Journal of Medical Genetics·D A Greenberg, J I Rotter
May 1, 1981·Annals of Human Genetics·F Clerget-DarpouxN Feingold
Sep 1, 1980·Diabetologia·I DeschampsJ Hors

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Citations

Jun 1, 1985·American Journal of Medical Genetics·D A Greenberg, S E Hodge
Nov 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·A N Gorsuch
Jan 1, 1986·Genetic Epidemiology. Supplement·D A Greenberg
Dec 1, 1984·Jinrui idengaku zasshi. The Japanese journal of human genetics·N Yasuda, T Sasazuki

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