The search for new antithrombotic mechanisms and therapies that may spare hemostasis.

Blood
Edward PlowDaniel I Simon

Abstract

Current antithrombotic drugs, including widely used antiplatelet agents and anticoagulants, are associated with significant bleeding risk. Emerging experimental evidence suggests that the molecular and cellular mechanisms of hemostasis and thrombosis can be separated, thereby increasing the possibility of new antithrombotic therapeutic targets with reduced bleeding risk. We review new coagulation and platelet targets and highlight the interaction between integrin αMβ2 (Mac-1, CD11b/CD18) on leukocytes and GPIbα on platelets that seems to distinguish thrombosis from hemostasis.

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May 23, 2018·Cancers·Sarah LuuRobert K Andrews
Jul 11, 2019·Future Medicinal Chemistry·Zhouling XieChenzhong Liao
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Aug 7, 2021·Journal of the American College of Cardiology·Charles HsuJeffrey I Weitz

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