The search for origins of DNA replication

Methods : a Companion to Methods in Enzymology
Melvin L DePamphilis

Abstract

The past decade has witnessed an explosion of new information about the nature of DNA replication in eukaryotic cells. Much of this information has resulted from the advent of novel methods for identifying and characterizing origins of DNA replication in the genomes of viruses, plasmids, and cells. These methods can map with remarkable precision sites where replication begins. In addition, they provide assays for origin activity that can be used to identify the sequence of events leading to the formation and activation of prereplication complexes at specific sites in chromosomal DNA. I summarize briefly the current view of eukaryotic replication origins and the methods that have been used to identify and characterize them. Selected methods that show promise for future applications are then described in detail in subsequent articles.

References

Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·L T Vassilev, M L DePamphilis
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T D Tlsty
Jun 16, 1989·Cell·S HandeliH Cedar
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W C BurhansN H Heintz
Jan 1, 1974·Cold Spring Harbor Symposia on Quantitative Biology·A B BlumenthalD S Hogness
Jun 1, 1995·Molecular and Cellular Biology·D M GilbertM L DePamphilis
Jan 1, 1994·Annual Review of Biochemistry·D Coverley, R A Laskey
Sep 1, 1994·Molecular and Cellular Biology·E S Tasheva, D J Roufa
Feb 4, 1994·Science·W C Burhans, J A Huberman
Jan 1, 1993·Annual Review of Biochemistry·M L DePamphilis
Jun 1, 1993·Current Opinion in Cell Biology·M L DePamphilis
Feb 2, 1996·The Journal of Biological Chemistry·M GenchevaG Russev
Apr 11, 1997·The Journal of Biological Chemistry·T ReinH Zorbas
Apr 1, 1997·Current Opinion in Genetics & Development·A Rowles, J J Blow
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·R K Clyne, T J Kelly
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·P A Dijkwel, J L Hamlin
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·J A Huberman
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·B A Boggs, A C Chinault
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·S A Gerbi, A K Bielinsky
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·M I Aladjem, G M Wahl
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·C Staib, F Grummt
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·J R WuD M Gilbert

❮ Previous
Next ❯

Citations

Jun 8, 2011·Human Gene Therapy·Claudia HagedornHans J Lipps
Apr 3, 2008·Genes & Development·Olivier CuvierMarcel Mechali
Sep 22, 2009·Genome Research·Romain DespratEric E Bouhassira
Apr 3, 2004·Molecular and Cellular Biology·Lixin WangMirit I Aladjem
Oct 11, 2012·Genes & Cancer·Domenic Di PaolaMaria Zannis-Hadjopoulos
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·A PemovJ L Hamlin
Jul 27, 2005·The Journal of Cell Biology·Jing WangZhigang He
Mar 13, 1999·The Journal of Biological Chemistry·P LawingerS Majumder
Dec 3, 2011·Journal of Cellular Biochemistry·Domenic Di Paola, Maria Zannis-Hadjopoulos
Mar 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M L DePamphilis
Sep 24, 2004·The Journal of Biological Chemistry·Javier R RevolloShin-ichiro Imai
Jul 11, 2002·The Journal of Biological Chemistry·Patricia A PioliWilliam F C Rigby
May 19, 2006·Cancer Research·Domenic Di PaolaMaria Zannis-Hadjopoulos
Nov 26, 1999·Biochimie·J Herrick, A Bensimon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Biology & Therapy
Jennifer L Bandura, Brian R Calvi
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Federico TessadoriRoel van Driel
Methods : a Companion to Methods in Enzymology
M I Aladjem, G M Wahl
© 2021 Meta ULC. All rights reserved