Jun 1, 1993

The search for the physiological functions of NTE; is NTE a receptor?

Chemico-biological Interactions
M Lotti, A Moretto

Abstract

Neuropathy target esterase (NTE) was identified as the molecular target for organophosphate-induced delayed polyneuropathy several years ago but its physiological functions are still unknown. The mechanism which initiates neuropathy was thought to be a two step process: inhibition (phosphorylation) of NTE and aging of phosphorylated NTE. Depending on the occurrence of the second reaction (aging), inhibitors were ranked as neuropathic (forming an ageable NTE) and non-neuropathic (forming a non-ageable NTE). Non-neuropathic inhibitors protect from neuropathy if given before the neuropathic ones, because they occupy the catalytic centre of NTE. Thus the catalytic function of NTE seems irrelevant in maintaining the health of neurons. This paper reviews some new information concerning the interaction of NTE with its inhibitors as well as on a phenomenon called promotion of neuropathy. Some inhibitors which apparently form a non-ageable inhibited NTE were found to cause neuropathy, even though some of them must be given at very high doses. Moreover some 'non-neuropathic-protective' NTE inhibitors were found to exacerbate (promote) neuropathy when given after a neuropathic one. It is likely that the target for promotion is other than ...Continue Reading

Mentioned in this Paper

Polyneuropathy
NTE, lymphocyte neuropathy target esterase
Isoflurophate
Hormone Receptors, Cell Surface
Neurons
Neuropathy target esterase
Protein Phosphorylation
Neuropathy
Molecular Target
Metabolic Inhibition

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