The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Ryoichi HamasunaMotonori Kano

Abstract

Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N. gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5 μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to oth...Continue Reading

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Citations

Dec 23, 2015·Expert Review of Anti-infective Therapy·Hyukmin LeeYunsop Chong
Jul 28, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Satoshi TakahashiMutsumasa Yoh
Sep 1, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Mitsuru YasudaTakashi Deguchi
Nov 21, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Agnez JönssonMagnus Unemo
Jan 25, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Yoshiki HiyamaShin-Ichi Yokota
Sep 2, 2016·Japanese Journal of Infectious Diseases·Chanwit TribuddharatSuthatta Sonprasert
Feb 18, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B Suay-García, M T Pérez-Gracia
Jul 30, 2017·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ana Paula Ramalho da Costa-LourençoRaquel Regina Bonelli
Feb 1, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ryoichi HamasunaUNKNOWN Japanese Association for Infectious Disease/Japanese Society of Chemotherapy, The JAID/JSC Guide/Guidelines to Clinical Mana
Feb 9, 2017·Sexually Transmitted Diseases·Mitsuru YasudaTakashi Deguch

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