The sedative and sympatholytic effects of oral tizanidine in healthy volunteers

Anesthesia and Analgesia
T J MiettinenM Scheinin

Abstract

Tizanidine, an imidazoline derivative with alpha 2-receptor-mediated central muscle relaxant activity, is in widespread clinical use for the treatment of spasticity. To evaluate its possible role in anesthesia we assessed the sedative and sympatholytic effects of orally administered tizanidine in a double-blind, placebo-controlled, randomized, cross-over study in six healthy male volunteers. Three different doses of tizanidine (4, 8, and 12 mg) were tested and compared to clonidine 150 micrograms. The sedative and sympatholytic effects of tizanidine 12 mg were comparable in magnitude to those of clonidine 150 micrograms, but the effects of clonidine were longer lasting. Similarly, the observed decreases in arterial blood pressure (diastolic, 13% and 19%; systolic, 10% and 8% for tizanidine and clonidine, respectively) and salivation were comparable in magnitude but of shorter duration after tizanidine 12 mg than after clonidine. Clonidine and tizanidine 12 mg had also similar effects on the secretion of growth hormone. Our results indicate that the effects of a single 12-mg oral dose of tizanidine resemble those of 150 micrograms oral clonidine, but are of shorter duration. Tizanidine may thus be a useful alternative to clonidi...Continue Reading

References

Mar 1, 1992·Journal of Clinical Anesthesia·M A SalonenM Maze
Jul 1, 1991·British Journal of Anaesthesia·U A CarabineJ Moore
Mar 1, 1991·British Journal of Anaesthesia·S BellaïcheF Roujas
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Nov 1, 1993·Pharmacology & Toxicology·M Salonen, M Maze
Jul 1, 1993·Acta Anaesthesiologica Scandinavica·R Aantaa, M Scheinin

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Citations

Oct 12, 2014·Current Cardiology Reports·Italo Biaggioni
May 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T KamibayashiM Maze
Jul 21, 2004·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Kazuyuki ImanagaRyo Ogawa
Jan 31, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L CsibaA B Guekht

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