The selective cannabinoid antagonist SR 141716A blocks cannabinoid-induced antinociception in rats

Pharmacology, Biochemistry, and Behavior
A H Lichtman, B R Martin

Abstract

The purported CB1 cannabinoid antagonist SR 141716A has proven to be a useful tool in the investigation of cannabinoid pharmacology. This antagonist was employed in the present study to investigate the antinociceptive and cataleptic effects of cannabinoids after either systemic or intracerebroventricular (ICV) administration. The antinociceptive potency of systemically administered delta 9-tetrahydrocannabinol (delta 9-THC) was decreased 18-fold by SR 141716A, from an ED50 value of 0.3-5.1 mg/kg. Similarly, it completely blocked the antinociceptive effects of delta 9-THC and CP 55,940, a potent bicyclic cannabinoid, after ICV administration. In addition, it prevented cannabinoid-induced catalepsy when given by either route of administration. In contrast, SR 141716A failed to antagonize the antinociceptive effects of morphine, indicating its selectivity for cannabinoid receptors. These findings indicate that the antinociceptive and cataleptic effects of delta 9-THC and CP 55,940 are mediated through CB1 cannabinoid receptors.

References

Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·B R MartinM Zhu
Jan 1, 1990·Annual Review of Physiology·A M Brown, L Birnbaumer
Nov 24, 1987·European Journal of Pharmacology·R PrzewłockiA Herz
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 27, 1986·European Journal of Pharmacology·M ParentiD Parolaro
Aug 25, 1995·European Journal of Pharmacology·M D AcetoB R Martin
May 1, 1995·Pharmacology, Biochemistry, and Behavior·J SouilhacP Soubrié
May 23, 1998·Annual Review of Pharmacology and Toxicology·C C Felder, M Glass

❮ Previous
Next ❯

Citations

Jan 18, 2006·Psychopharmacology·Graciela N BalerioRafael Maldonado
Jan 7, 2004·Life Sciences·Diana L Cichewicz
Jun 28, 2001·European Journal of Pharmacology·E FrideR Mechoulam
Oct 31, 1998·European Journal of Pharmacology·A H LichtmanB R Martin
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Jano J JanoyanNissar A Darmani
May 26, 1999·Pharmacology & Therapeutics·S H Burstein
Jul 9, 2002·Brain Research. Developmental Brain Research·Eva M RomeroM Paz Viveros
Feb 13, 2001·Progress in Neurobiology·R G Pertwee
May 17, 2000·Drug and Alcohol Dependence·M K Greenwald, M L Stitzer
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·M Costigan, C J Woolf
Sep 12, 1998·Nature Medicine·H L Fields, I D Meng
Mar 6, 2007·Neuropharmacology·Lindsay B HoughRebecca Stadel
Feb 4, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ahmet DogrulAhmet Ulugol
Jul 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Angela N Henderson-RedmondDaniel J Morgan
Sep 11, 2007·British Journal of Pharmacology·K ReaD P Finn
Jul 25, 2014·Pharmacology, Biochemistry, and Behavior·Travis W GrimAron H Lichtman
Oct 1, 2011·Pharmacology, Biochemistry, and Behavior·Aldric Hama, Jacqueline Sagen
Jul 12, 2005·Expert Opinion on Investigational Drugs·Alyson Fox, Stuart Bevan
Dec 7, 2002·Pain·L R GardellF Porreca
Aug 23, 2007·Chemistry & Biodiversity·Barbara Costa
Mar 29, 2003·The Journal of Pharmacology and Experimental Therapeutics·Stefania RuiuLuca Pani
Aug 15, 2015·Anesthesia and Analgesia·Zheng-Lan HanRui Wang
Sep 20, 2016·Current Addiction Reports·Ryan BogdanArpana Agrawal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.