The selective estrogen receptor modulators in breast cancer prevention

Cancer Chemotherapy and Pharmacology
Fangxuan LiJuntian Liu

Abstract

Persistently increased blood levels of estrogens are associated with an increased risk of breast cancer. Selective estrogen receptor modulators (SERMs) are a class of compounds that act on the estrogen receptor (ER). Several clinical trials have demonstrated the effectiveness of its prophylactic administration. Incidence of invasive ER-positive breast cancer was reduced by SERMs treatment, especially for those women with high risk of developing breast cancer. In this study, we reviewed the clinical application of SERMs in breast cancer prevention. To date, four prospective randomized clinical trials had been performed to test the efficacy of tamoxifen for this purpose. Concerning on the benefit and cost of tamoxifen, various studies from different countries demonstrated that chemoprevention with tamoxifen seemed to be cost-effective for women with a high risk of invasive breast cancer. Based above, tamoxifen was approved for breast cancer prevention by the US Food and Drug Administration in 1998. Raloxifene was also approved for postmenopausal women in 2007 for breast cancer prevention which reduces the risk of invasive breast cancer with a lower risk of unwanted stimulation of endometrium. Thus, raloxifene is considered to hav...Continue Reading

References

Oct 17, 1998·Journal of the National Cancer Institute·A DecensiU Veronesi
Jan 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J Smith, B E Hillner
Nov 17, 2001·JAMA : the Journal of the American Medical Association·M C KingUNKNOWN National Surgical Adjuvant Breast and Bowel Project
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn HershmanVictor R Grann
Jan 17, 2003·Journal of the National Cancer Institute·Umberto VeronesiUNKNOWN Italian Tamoxifen Study Group
Apr 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G R de LimaL H Gebrim
Jun 5, 2003·Journal of the National Cancer Institute·Andrea DecensiUmberto Veronesi
Aug 9, 2003·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Andrea DecensiUmberto Veronesi
Jan 7, 2004·Australian and New Zealand Journal of Public Health·Simon D EckermannR John Simes
Sep 2, 2004·Obstetrics and Gynecology·Samuel CykertCharles Hansen
Dec 2, 2004·Journal of the National Cancer Institute·Silvana MartinoUNKNOWN CORE Investigators
Jan 20, 2006·The New England Journal of Medicine·James D Yager, Nancy E Davidson
Jun 7, 2006·JAMA : the Journal of the American Medical Association·Victor G VogelUNKNOWN National Surgical Adjuvant Breast and Bowel Project (NSABP)
Jul 14, 2006·The New England Journal of Medicine·Elizabeth Barrett-ConnorUNKNOWN Raloxifene Use for The Heart (RUTH) Trial Investigators
Jul 26, 2006·Cancer·Joy MelnikowJames Nuovo
Feb 22, 2007·Journal of the National Cancer Institute·Jack CuzickUNKNOWN International Breast Cancer Intervention Study I Investigators
Feb 22, 2007·Journal of the National Cancer Institute·Trevor J PowlesMitch Dowsett
May 2, 2007·Journal of the National Cancer Institute·Umberto VeronesiUNKNOWN Italian Tamoxifen Study Group
Aug 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea DecensiBernardo Bonanni
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kala VisvanathanUNKNOWN American Society of Clinical Oncology
Feb 26, 2010·The New England Journal of Medicine·Steven R CummingsUNKNOWN PEARL Study Investigators
Apr 21, 2010·Cancer Prevention Research·Victor G VogelUNKNOWN National Surgical Adjuvant Breast and Bowel Project
Jul 27, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven R CummingsClaus Christiansen
Oct 26, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·Therese B BeversJohn H Ward
Nov 6, 2010·Journal of the National Cancer Institute·Andrea Z LaCroixUNKNOWN PEARL Investigators
Jul 23, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S L SilvermanUNKNOWN Bazedoxifene Study Group
Apr 10, 2012·Breast Cancer Research and Treatment·Trevor J PowlesSteven R Cummings
May 25, 2012·Breast Cancer Research and Treatment·Erika A WatersAndrew N Freedman
Apr 16, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Frank DetterbeckAmanda Reid
May 4, 2013·Lancet·Jack CuzickUNKNOWN SERM Chemoprevention of Breast Cancer Overview Group
Jul 19, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A DeCensiUNKNOWN Italian HOT Study Group
Aug 7, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kelly-Anne PhillipsJohn L Hopper
Aug 21, 2013·Current Breast Cancer Reports·Laura Reimers, Katherine D Crew
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
Apr 24, 2014·Future Oncology·Kelly-Anne Phillips, Geoffrey J Lindeman
Nov 14, 2014·Journal of the National Cancer Institute·Montserrat Garcia-ClosasNilanjan Chatterjee

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Citations

Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jia LiuZhong-Hou Han
Nov 7, 2019·Journal of Cellular Biochemistry·Wen-Jing LiuSheng-Xiang Lin
Dec 20, 2017·Expert Opinion on Drug Discovery·Mohamed AliAyman Al-Hendy
Jun 6, 2018·Frontiers in Endocrinology·Heather M BondGiovanni Morrone
Jan 10, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Liliana RaimundoLucília Saraiva

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