The selective impairment of resting-state functional connectivity of the lateral subregion of the frontal pole in schizophrenia

PloS One
Yujing ZhouChunshui Yu

Abstract

Although extensive resting-state functional connectivity (rsFC) changes have been reported in schizophrenia, rsFC changes of the frontal pole (FP) remain unclear. The FP contains several subregions with different connection patterns; however, it is unknown whether the FP subregions are differentially affected in schizophrenia. To explore this possibility, we compared rsFC differences of the FP subregions between schizophrenia patients and healthy controls. One hundred healthy controls and 91 patients with schizophrenia underwent resting-state functional MRI with a sensitivity-encoded spiral-in (SENSE-SPIRAL) imaging sequence to reduced susceptibility-induced signal loss and distortion. The FP was subdivided into the orbital (FPo), medial (FPm), and lateral (FPl) subregions. Mean fMRI time series were extracted for each FP subregion and entered into a seed-based rsFC analysis. The FP subregions exhibited differential rsFC patterns in both healthy controls and schizophrenia patients. Direct comparison between groups revealed reduced rsFCs between the bilateral FPl and several cognitive-related regions, including the dorsolateral prefrontal cortex, medial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex/pre...Continue Reading

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Citations

May 5, 2016·Schizophrenia Bulletin·Ewa BulzackaUNKNOWN FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) Group
Jan 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·A C AltamuraP Brambilla
Jun 29, 2021·Psychophysiology·Guangcan XiangHong Chen

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Methods Mentioned

BETA
imaging technique

Software Mentioned

Statistical Parametric Mapping SPM8
SPM8

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